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CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population

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An Erratum to this article was published on 08 April 2010

Abstract

Oxidative stress is believed to play an important role in the pathogenesis of considerable number of complex diseases. The antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPX) are important components of cell defense against oxidative stress, and polymorphisms in the genes which regulate their expression may contribute to differences in susceptibility of individuals to oxidative damage caused by reactive oxygen species. The aim of this study was to assess the distribution of CAT C-262T and GPX1 Pro198Leu genotypic variants in a Turkish population. Genotyping analyses of CAT and GPX1 were conducted in 250 unrelated, healthy volunteers by the PCR-RFLP assay. The allele frequencies were 0.784 (C) and 0.216 (T) for CAT and 0.636 (C) and 0.364 (T) for GPX1 Pro198Leu. The genotype frequencies were 0.632 (CC), 0.304 (CT), and 0.064 (TT) for CAT and 0.416 (CC), 0.44 (CT), and 0.144 (TT) for GPX1 Pro198Leu. The genotype frequencies did not deviate from Hardy–Weinberg equilibrium. The results are compared with those of other reported populations. They showed marked ethnic group differences.

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Acknowledgments

This work was supported by the Research Fund of Ankara University, Project No. 2008.080.059. The authors would like to express their sincere thanks to Dr. Tansel Eke for providing blood samples from the unrelated, healthy population.

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Authors and Affiliations

  1. Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, 06100, Ankara, Turkey

    H. Sinan Suzen, Emel Gucyener, Ozgul Sakalli, Zuhal Uckun, Gulcin Kose, Duygu Ustel & Yalcin Duydu

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  1. H. Sinan Suzen
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  2. Emel Gucyener
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Correspondence to H. Sinan Suzen.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s11033-010-0154-7

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Suzen, H.S., Gucyener, E., Sakalli, O. et al. CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population. Mol Biol Rep 37, 87–92 (2010). https://doi.org/10.1007/s11033-009-9540-4

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  • DOI: https://doi.org/10.1007/s11033-009-9540-4

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