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Synthesis of sterically congested 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, N,N-dicyclohexylcarbodiimide and (N-isocyanimino)triphenylphosphorane

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Abstract

Reactions of (N-isocyanimino)triphenylphosphorane with N,N-dicyclohexylcarbodiimide in the presence of aromatic (or heteroaromatic) carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions were observed.

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Authors and Affiliations

  1. Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran

    Fatemeh Zeinali Nasrabadi & Ali Ramazani

  2. Young Researchers Club, Islamic Azad University, Zanjan Branch, Zanjan, Iran

    Yavar Ahmadi

Authors
  1. Fatemeh Zeinali Nasrabadi
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  2. Ali Ramazani
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  3. Yavar Ahmadi
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Correspondence to Ali Ramazani.

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Nasrabadi, F.Z., Ramazani, A. & Ahmadi, Y. Synthesis of sterically congested 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, N,N-dicyclohexylcarbodiimide and (N-isocyanimino)triphenylphosphorane. Mol Divers 15, 791–798 (2011). https://doi.org/10.1007/s11030-011-9310-9

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  • DOI: https://doi.org/10.1007/s11030-011-9310-9

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