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Intramolecular cyclization of 1-(2-arylethyl)tetrahydro-6-hydroxy-1H-pyrimidin-2-thiones: effect of substituents on reactivity

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Abstract

Convenient synthetic procedures for 1,2,3,6,7, 11b-hexahydro-4H-pyrimido[6, 1 -a] isoquinolin-4-thiones and 2,3,6,7,12,12b-hexahydro-1H-pyrimido[1′,6′:1,2]pyrido[3,4-b]indole-4-thiones have been developed. Structural factors which influence on a cascade cyclization process have been elucidated.

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  1. Omsk F.M. Dostoevsky State University, Mira Prospect 55A, Omsk, 644077, Russia

    Alexander S. Fisuyk, Aleksey Y. Mukanov & Nikolay V. Poendaev

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  1. Alexander S. Fisuyk
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  2. Aleksey Y. Mukanov
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  3. Nikolay V. Poendaev
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Correspondence to Nikolay V. Poendaev.

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Fisuyk, A.S., Mukanov, A.Y. & Poendaev, N.V. Intramolecular cyclization of 1-(2-arylethyl)tetrahydro-6-hydroxy-1H-pyrimidin-2-thiones: effect of substituents on reactivity. Mol Divers 14, 455–462 (2010). https://doi.org/10.1007/s11030-010-9239-4

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  • DOI: https://doi.org/10.1007/s11030-010-9239-4

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