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New insights of DsbA-L in the pathogenesis of metabolic diseases

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Abstract

Metabolic diseases, such as obesity, diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD), are abnormal conditions that result from disturbances of metabolism. With the improvement of living conditions, the morbidity and mortality rates of metabolic diseases are steadily rising, posing a significant threat to human health worldwide. Therefore, identifying novel effective targets for metabolic diseases is crucial. Accumulating evidence has indicated that disulfide bond A oxidoreductase-like protein (DsbA-L) delays the development of metabolic diseases. However, the underlying mechanisms of DsbA-L in metabolic diseases remain unclear. In this review, we will discuss the roles of DsbA-L in the pathogenesis of metabolic diseases, including obesity, diabetes mellitus, and NAFLD, and highlight the potential mechanisms. These findings suggest that DsbA-L might provide a novel therapeutic strategy for metabolic diseases.

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Acknowledgements

The authors would like to thank all the reviewers who participated in the review and BioRender (BioRender.com) for the Figure 1.

Funding

This work was supported by the National Natural Science Foundation of China [81500036], Scientific Research Fund of Hunan Provincial Education Department [21B0005], Hunan Provincial Natural Science Foundation [2022JJ30917, 2022JJ30832], and Special Fund for Rehabilitation Medicine of the National Clinical Research Center for Geriatric Disorders Clinical Research Fund [2021KFJJ09].

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Authors and Affiliations

  1. Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China

    Siqi Li, Qiong Huang & Baimei He

  2. Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China

    Siqi Li, Qiong Huang & Baimei He

  3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China

    Siqi Li, Qiong Huang & Baimei He

  4. Department of Emergency Medicine, Southwest Hospital, Army Medical University, Chongqing, 400038, China

    Jinfa Wan

  5. Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China

    Zhenyu Peng

  6. Emergency Medicine and Difficult Diseases Institute, Central South University, Changsha, 410011, China

    Zhenyu Peng

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Contributions

Siqi Li: Writing- Original draft preparation. Jinfa Wan and Qiong Huang: Writing- Reviewing and Editing. Zhenyu Peng: Conceptualization. Baimei He: Supervision, Writing- Reviewing and Editing.

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Correspondence to Baimei He.

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Li, S., Wan, J., Peng, Z. et al. New insights of DsbA-L in the pathogenesis of metabolic diseases. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-024-04964-8

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