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The role of WWP1 and WWP2 in bone/cartilage development and diseases

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Abstract

Bone and cartilage diseases are often associated with trauma and senescence, manifested as pain and limited mobility. The repair of bone and cartilage lesion by mesenchymal stem cells is regulated by various transcription factors. WW domain-containing protein 1 (WWP1) and WW domain-containing protein 2 (WWP2) are named for WW domain which recognizes PPXY (phono Ser Pro and Pro Arg) motifs of substrate. WWP1and WWP2 are prominent components of the homologous to the E6-AP carboxyl terminus (HECT) subfamily, a group of the ubiquitin ligase. Recently, some studies have found that WWP1 and WWP2 play an important role in the pathogenesis of bone and cartilage diseases and regulate the level and the transactivation of various transcription factors through ubiquitination. Therefore, this review summarizes the distribution and effects of WWP1 and WWP2 in the development of bone and cartilage, discusses the potential mechanism and therapeutic drugs in bone and cartilage diseases such as osteoarthritis, fracture, and osteoporosis.

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Funding

This work was supported by the grants from the National Natural Science Foundation of China (82170984) and Zhejiang Provincial Natural Science Foundation of China under Grant NO.LQ24H140004.

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  1. Ying Wang and Zuping Wu have contributed equally to this work and share first authorship.

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  1. Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310016, China

    Ying Wang, Zuping Wu, Cunyi Wang, Na Wu, Chenyu Wang, Shiyu Hu & Jiejun Shi

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JS conceptualized the review, CW and CW performed the literature search, YW wrote the original draft, ZW reviewed and edited the manuscript, and SH and NW were responsible for supervision.

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Wang, Y., Wu, Z., Wang, C. et al. The role of WWP1 and WWP2 in bone/cartilage development and diseases. Mol Cell Biochem (2024). https://doi.org/10.1007/s11010-023-04917-7

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