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Emerging role of lipophagy in liver disorders

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Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Abstract

Lipophagy is a selective degradation of lipids by a lysosomal-mediated pathway, and dysregulation of lipophagy is linked with the pathological hallmark of many liver diseases. Downregulation of lipophagy in liver cells results in abnormal accumulation of LDs (Lipid droplets) in hepatocytes which is a characteristic feature of several liver pathologies such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Contrarily, upregulation of lipophagy in activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and cirrhosis. Lipid metabolism reprogramming in violent cancer cells contributes to the progression of liver cancer. In this review, we have summarized the recent studies focusing on various components of the lipophagic machinery that can be modulated for their potential role as therapeutic agents against a wide range of liver diseases.

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  1. Bismillah Nazeer, Muhammad Babar Khawar, Muhammad Usman Khalid, Syeda Eisha Hamid, Mussarat Rafiq have contributed equally to this work.

Authors and Affiliations

  1. Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences, University of Central Punjab, Lahore, Pakistan

    Bismillah Nazeer, Muhammad Usman Khalid, Syeda Eisha Hamid, Ahmad Ali, Hooriya Fatima & Sadia Ahmad

  2. Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan

    Muhammad Babar Khawar

  3. Department of Zoology, University of Okara, Okara, Pakistan

    Muddasir Hassan Abbasi

  4. Cell and Molecular Biology Lab, Institute of Zoology, University of the Punjab, Lahore, Pakistan

    Mussarat Rafiq & Nadeem Sheikh

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  1. Bismillah Nazeer
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Contributions

BN, MBK MUK, MR, SHE, HF, and SA collected the data, created the Tables, and wrote the manuscript; BN, MBK, MUK, and SHE, AA, AA draw the figures. MBK, SHE, and MR proofread the review and help out in improving the manuscript; MBK, MHA, and NS proposed the idea, supervised, and approved the final version of the manuscript.

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Correspondence to Muhammad Babar Khawar, Muddasir Hassan Abbasi or Nadeem Sheikh.

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Nazeer, B., Khawar, M.B., Khalid, M.U. et al. Emerging role of lipophagy in liver disorders. Mol Cell Biochem 479, 1–11 (2024). https://doi.org/10.1007/s11010-023-04707-1

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