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Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance

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Abstract

Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.

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Acknowledgements

This work was financed by the Ministry of Science and Higher Education of the Russian Federation within the framework of state support for the creation and development of World-Class Research Centers "Digital biodesign and personalized healthcare" No. 075-15-2020-926.

Funding

This work is supported by Russian Science Foundation under grant No. 21-15-00213 (IU, description of molecular mechanisms of autophagy).

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Authors and Affiliations

  1. Group of Experimental Biotherapy and Diagnostics, Institute for Regenerative Medicine, World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov First Moscow State Medical University, Moscow, Russia, 119991

    Elizaveta Belyaeva, Ilya V. Ulasov & Irina Karlina

  2. Endocrine Research Laboratory, Department of Zoology, Kutir Post Graduate College, Chakkey, Jaunpur, UP, India

    Rajesh Kumar Kharwar

  3. Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Moscow, Russian Federation, 119991

    Petr Timashev

  4. Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, 4 Kosygin st., Moscow, Russian Federation, 119991

    Petr Timashev

  5. Chemistry Department, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow, Russian Federation, 119991

    Petr Timashev

  6. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

    Reza Mohammadinejad

  7. Tumor Immunology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, UP, 221005, India

    Arbind Acharya

Authors
  1. Elizaveta Belyaeva
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  2. Rajesh Kumar Kharwar
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  3. Ilya V. Ulasov
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  4. Irina Karlina
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  5. Petr Timashev
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  6. Reza Mohammadinejad
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  7. Arbind Acharya
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Contributions

EB: Conception, design, writing – review & editing. RKK: revising the manuscript, drafting, editing. IVU: supervise, critically edited and approved find draft for submission. PT: Revising and approve the final manuscript for submission. IK-editing manuscript; RM: revising and approve the manuscript to be published. AA: Revising critically and approve the final manuscript for submission.

Corresponding authors

Correspondence to Ilya V. Ulasov or Arbind Acharya.

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Belyaeva, E., Kharwar, R.K., Ulasov, I.V. et al. Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance. Mol Cell Biochem 477, 593–604 (2022). https://doi.org/10.1007/s11010-021-04308-w

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  • DOI: https://doi.org/10.1007/s11010-021-04308-w

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