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Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia

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Abstract

The aim of our study was to investigate the effects of one-month consumption of polyphenol-rich standardized Aronia melanocarpa extract (SAE) on redox status in anemic hemodialysis patients. The study included 30 patients (Hb < 110 g/l, hemodialysis or hemodiafiltration > 3 months; > 3 times week). Patients were treated with commercially available SAE in a dose of 30 ml/day, for 30 days. After finishing the treatment blood samples were taken to evaluate the effects of SAE on redox status. Several parameters of anemia and inflammation were also followed. After the completion of the treatment, the levels of superoxide anion radical and nitrites significantly dropped, while the antioxidant capacity improved via elevation of catalase and reduced glutathione. Proven antioxidant effect was followed by beneficial effects on anemia parameters (increased hemoglobin and haptoglobin concentration, decreased ferritin and lactate dehydrogenase concentration), but SAE consumption didn't improve inflammatory status, except for minor decrease in C-reactive protein. The consumption of SAE regulates redox status (reduce the productions of pro-oxidative molecules and increase antioxidant defense) and has beneficial effects on anemia parameters. SAE could be considered as supportive therapy in patients receiving hemodialysis which are prone to oxidative stress caused by both chronic kidney disease and hemodialysis procedure. Additionally, it could potentially be a good choice for supplementation of anemic hemodialysis patients. TRN: NCT04208451 December 23, 2019 “retrospectively registered”

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Data are available from the correspondence author upon reasonable request.

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Acknowledgements

This research was supported by the Faculty of Medical Sciences, University of Kragujevac. Authors express special thanks to Pharmanova, Belgrade, Serbia for donation of polyphenol-rich standardized Aronia melanocarpa extract.

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Authors and Affiliations

  1. Faculty of Medical Sciences, Department of Pharmacy, University of Kragujevac, Kragujevac, Serbia

    Isidora Milosavljevic, Nevena Draginic & Jovana Jeremic

  2. Faculty of Medical Sciences, Department of Physiology, University of Kragujevac, Svetozara Markovica 69, 34000, Kragujevac, Serbia

    Vladimir Jakovljevic, Vladimir Zivkovic & Ivan Srejovic

  3. Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Moscow, Russia

    Vladimir Jakovljevic & Sergey Bolevich

  4. Faculty of Medical Sciences, Department of Internal Medicine, University of Kragujevac, Kragujevac, Serbia

    Dejan Petrovic & Nebojsa Andjelkovic

  5. Pharmanova, Belgrade, Serbia

    Miroslav Mitrovic

  6. Faculty of Medical Sciences, Department of Medical Statistics and Informatics, University of Kragujevac, Kragujevac, Serbia

    Vladislava Stojic

Authors
  1. Isidora Milosavljevic
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  2. Vladimir Jakovljevic
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  3. Dejan Petrovic
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  4. Nevena Draginic
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  5. Jovana Jeremic
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  8. Ivan Srejovic
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  9. Vladislava Stojic
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  10. Sergey Bolevich
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Contributions

Conceptualization, V.J. and S.B.; Writing–original draft preparation, I.M. and N.D.; Methodology, D.P. and N.A.; Software, V.S.; Resources, M.M.; Investigation, J.J. and I.S.; Supervision, V.Z. All authors contributed substantially to the work reported. All authors have read and agreed to the final version of the manuscript.

Corresponding author

Correspondence to Vladimir Jakovljevic.

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The authors declare no conflict of interest.

Ethical approval

Study is approved by the Ethics Committee of the Clinical Center Kragujevac, Serbia No 01-14-3039.

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All patients gave written informed consent to participate in the study.

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All patients gave written informed consent for publication of data.

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Milosavljevic, I., Jakovljevic, V., Petrovic, D. et al. Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia. Mol Cell Biochem 476, 4167–4175 (2021). https://doi.org/10.1007/s11010-021-04225-y

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