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Evaluation Anti-inflammatory Effect of Conjugated Gold Nanoparticles with Cortistatin Peptide as Drug Delivery to Asthmatic Lung Tissue

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International Journal of Peptide Research and Therapeutics Aims and scope Submit manuscript

Abstract

Asthma is an inflammatory disease that affects the airways. Inflammation of the airway and reversible bronchoconstriction eventually lead to obstruction of the airways, breathlessness and asthma attack. Gold nanoparticles are among the most widely used nanoparticles and have many applications for pharmaceutical and medical purposes. Cortistatin is a neuropeptide that exhibits anti-inflammatory effects. In this study, spherical gold nanoparticles were conjugated to the Cortistatin peptide, for effective and targeted drug delivery to the airways of asthmatic mice. After synthesizing spherical gold nanoparticles and conjugation the Cortistatin, asthma model was produced and treatment with a nano-drug. The levels of inflammatory cytokines, Specific and total IgE, inflammatory gene expression, the number of goblet cells, and the amount of mucus secretion and eosinophilic inflammation in lung tissues were studied. The results showed that Cortistatin-nanoparticle could control allergic and inflammatory factors and the anti-inflammatory effects of Cortistatin peptide-bound nanoparticle are far greater than those of the peptide alone. Increasing the anti-inflammatory effect of peptide-bound nanoparticle versus peptide alone, confirmed the effective, targeted and correct drug delivery of peptide-nanoparticle combination to inflamed areas in lung tissue.

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Acknowledgements

The authors have thanks Zanjan University of Medical Sciences and Ilam Branch, Islamic Azad University for their supports.

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Authors and Affiliations

  1. Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran

    Didar Mehrabi Nasab & Alireza Taheri

  2. Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

    Seyyed Shamsadin Athari

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  1. Didar Mehrabi Nasab
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  2. Alireza Taheri
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  3. Seyyed Shamsadin Athari
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DMN, AT, and SSA have participated in the design, investigation, and drafting the manuscript.

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Correspondence to Alireza Taheri or Seyyed Shamsadin Athari.

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All of the protocols were approved by the Ethics Committees, Zanjan University of Medical Sciences, (NO: IR.ZUMS.REC.1400.156).

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Mehrabi Nasab, D., Taheri, A. & Athari, S.S. Evaluation Anti-inflammatory Effect of Conjugated Gold Nanoparticles with Cortistatin Peptide as Drug Delivery to Asthmatic Lung Tissue. Int J Pept Res Ther 29, 16 (2023). https://doi.org/10.1007/s10989-022-10487-x

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  • DOI: https://doi.org/10.1007/s10989-022-10487-x

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