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Microcalorimetric study of the effect of l-borneol, d-borneol and synthetic borneol on the growth of P. aeruginosa

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Abstract

Properties theory of traditional Chinese medicine has been used thousands of years. Borneol, an important drug, was widely used for acute illness—“Rebi” in Chinese. However, in Chinese Pharmacopoeia (Ch.P), borneol is recorded as three kinds: l-borneol (B1), d-borneol (B2) and synthetic borneol (B3). In the study, the power–time (P–t) curves generated by P. aeruginosa which were disturbed by borneol were investigated through microcalorimetry; afterward, some thermo-kinetic parameters were obtained from the curves to characterize the metabolism of P. aeruginosa. The parameters were analyzed by principal component analysis. The results showed that borneol expressed different drugs properties. The half-maximal influences concentration (IC50) value of B1 was lower than those of B2 and B3. Especially, the IC50 of B1 was 447.185 μg mL−1. The influences of three kinds of borneol were l-borneol (B1) > synthetic borneol (B3) > d-borneol (B2), which met the long-term cognition. This could provide guidance for clinical use of borneol with different drugs properties.

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Abbreviations

TCM:

Traditional Chinese medicine

Ch.P:

Chinese Pharmacopoeia

B1 :

l-borneol

B2 :

d-borneol

B3 :

Synthetic borneol

PCA:

Principal component analysis

I :

Influence rate

IC50:

Half-maximal inhibitory concentration

CHM:

Chinese herbal medicine

CGMCC:

China General Microbiological Culture Collection Center

LB:

Luria–Bertani

TAM:

Thermal activity monitor

CFU:

Colony-forming units

PCs:

Principal components

PLS-DA:

Partial least squares discriminant analysis

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Acknowledgements

The authors thank reviewers for their critical comments provided during revision and also wish to thank all authors of references. This work was financially supported by grants from National Natural Science Foundation of China (81473371, 81703725 and J1310034) and Sichuan Province Clinical Chinese Pharmacy Science and Technology Innovation Youth Team (2017TD0001).

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Authors and Affiliations

  1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China

    Xiao Ma, Qian Xie, Mingquan Wu, Jian Wang, Jianxia Wen, Rong Ma & Taiwei Dong

  2. Department of Pharmacy, 302 Hospital of People’s Liberation Army, Beijing, 100039, China

    Mingquan Wu, Yanling Zhao & Jianxia Wen

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  1. Xiao Ma
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  2. Qian Xie
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  3. Mingquan Wu
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Correspondence to Jian Wang.

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Ma, X., Xie, Q., Wu, M. et al. Microcalorimetric study of the effect of l-borneol, d-borneol and synthetic borneol on the growth of P. aeruginosa . J Therm Anal Calorim 131, 1681–1689 (2018). https://doi.org/10.1007/s10973-017-6627-3

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