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Thermodynamics of molecular complexation of glycyl–glycyl–glycine with cryptand [2.2.2] in water–dimethylsulfoxide solvent at 298.15 K

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Abstract

The influence of water–dimethylsulfoxide (H2O–DMSO) solvent on the reaction of the molecular complex formation between cryptand [2.2.2] (L) and glycyl–glycyl–glycine (3Gly) was studied at T = 298.15 K. The thermodynamic parameters for the reaction (lgK 0, Δr G 0, Δr H 0, TΔr S 0) were obtained from calorimetric titration experiments carried out by means of the calorimetric system TAM III (TA Instruments, USA). The binding mode of 3Gly–L complexation in H2O–DMSO solvent was determined by NMR spectroscopy, and the spectroscopic data were also used to calculate the [3GlyL] stability constants. A slight increase in complex stability and reaction exothermicity was observed at increasing DMSO content. The thermodynamic parameters for [3GlyL] are compared with thermodynamic parameters of complex formation of 18-crown-6 with amino acids and 3Gly in mixed solvents using the solvation-thermodynamic approach.

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Acknowledgements

The study was carried out in the Research Institute of Thermodynamics and Kinetics of Chemical Processes of the Ivanovo State University of Chemistry and Technology in the framework of the State Assignment of the Ministry of Education and Science of the Russian Federation (Project No. 2293). We thank “The upper Volga region centre of physicochemical research” (Institute of Solution Chemistry of RAS) for the NMR equipment used in this work.

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Authors and Affiliations

  1. Ivanovo State University of Chemistry and Technology, pr. Sheremetevski 7, Ivanovo, Russia, 153000

    T. R. Usacheva & V. A. Sharnin

  2. Institute for Tropical Technology, Vietnam Academy of Science and Technology, Hoang Quoc Viet str. 18, Cau Giay, Hanoi, Vietnam

    L. Pham Thi

  3. G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskaya str. 1, Ivanovo, Russia, 153045

    I. V. Terekhova, R. S. Kumeev & V. A. Sharnin

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  1. T. R. Usacheva
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Usacheva, T.R., Pham Thi, L., Terekhova, I.V. et al. Thermodynamics of molecular complexation of glycyl–glycyl–glycine with cryptand [2.2.2] in water–dimethylsulfoxide solvent at 298.15 K. J Therm Anal Calorim 126, 307–314 (2016). https://doi.org/10.1007/s10973-016-5383-0

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  • DOI: https://doi.org/10.1007/s10973-016-5383-0

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