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Synthesis, spectral, thermal, and antimicrobial studies of transition metal complexes of atorvastatin calcium as a lipid-lowering agent

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Abstract

Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)2(Cl)(H2O)]·5H2O (1), [Mn(AVT)2(H2O)2] (2), [Fe(AVT)2(Cl)(H2O)]·9H2O (3), [Co(AVT)2(H2O)2]·8H2O (4), [Ni(AVT)2(H2O)2]·4H2O (5), [Cu(AVT)2(H2O)2] (6), [Zn(AVT)2]·2H2O (7), [Pt(AVT)2(Cl)2] (8), [Au(AVT)3] (9), and [Pd(AVT)(Cl)2] (10) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.

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Acknowledgements

This work was supported by grants from Princess Nora Bint Abdul Rahman University, Riyadh, Saudi Arabia under project Grants No. 22/32.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

    Moamen S. Refat

  2. Department of Chemistry, Faculty of Science, Taif University, P.O. Box 888, Taif, Kingdom Saudi Arabia

    Moamen S. Refat

  3. Department of Chemistry, Faculty of Science, Princess Nora Bint Abdul Rahman University, Riyadh, Kingdom Saudi Arabia

    Foziah A. Al-Saif

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Correspondence to Moamen S. Refat.

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Refat, M.S., Al-Saif, F.A. Synthesis, spectral, thermal, and antimicrobial studies of transition metal complexes of atorvastatin calcium as a lipid-lowering agent. J Therm Anal Calorim 120, 863–878 (2015). https://doi.org/10.1007/s10973-014-3784-5

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