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Investigation of thermal behavior of Heliotropium indicum L. lyophilized extract by TG and DSC

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Abstract

Thermogravimetric (TG) techniques and differential scanning calorimetry (DSC) used for the study of pre-formulation or drug–adjuvant compatibility have been gaining importance in Brazil. These techniques are being used for the verification of possible interactions between drugs and adjuvants. Aiming at studying the behavior of a plant extract and its mixture with adjuvants, using these thermoanalytical techniques the plant species Heliotropium indicum L. was used. This plant which is originally from India and has been well acclimatized in Brazil has healing and anti-inflammatory properties. The methodology for obtaining the extract followed the Brazilian Pharmacopoeia methodology. And the incorporation of the extract with adjuvants was through binary mixtures (1:1 w/w). The TG and DSC curves were obtained under nitrogen atmosphere (25 mL min−1) at a heating rate of 5 °C min−1; TG tests were analyzed within a temperature range from 25 to 600 °C and DSC from 25 to 300 °C. The TG curves show good thermal stability of the extract and its mixtures with adjuvants up to 150 °C, except the propylene glycol (PLG). The DSC curves revealed an incompatibility of the extract with methylparaben and PLG mixture.

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Acknowledgements

The authors thank the Coordination of Improvement of Higher Education Personnel (CAPES), the Research Support Foundation of the State of Pará (FAPESPA), the Research and Development Foundation (FADESP) and Dean of Graduate Studies and Research (PROPESP/UFPA).

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Authors and Affiliations

  1. Laboratory of Pharmacotechnical Research and Development, College of Pharmacy, Federal University of Pará, Augusto Corrêa Street, 01-Guamá, Belém, PA, 66075-110, Brazil

    Russany Silva da Costa, Sarah Regina Pereira Camelo & José Otávio Carréra Silva Júnior

  2. Laboratory of Catalysis and Oleochemistry, College of Chemistry, Federal University of Pará, Augusto Corrêa Street, 01-Guamá, Belém, PA, 66075-110, Brazil

    Charles Alberto Brito Negrão & Carlos Emmerson Ferreira da Costa

  3. Laboratory of Quality Control of Medicines, College of Pharmacy, Federal University of Pará, Augusto Corrêa Street, 01-Guamá, Belém, PA, 66075-110, Brazil

    Roseane Maria Ribeiro-Costa

  4. Laboratory of Phytochemistry, College of Pharmacy, Federal University of Pará, Augusto Corrêa Street, 01-Guamá, Belém, PA, 66075-110, Brazil

    Wagner Luiz Ramos Barbosa

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  1. Russany Silva da Costa
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  2. Charles Alberto Brito Negrão
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  3. Sarah Regina Pereira Camelo
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  4. Roseane Maria Ribeiro-Costa
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  7. José Otávio Carréra Silva Júnior
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Correspondence to José Otávio Carréra Silva Júnior.

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da Costa, R.S., Negrão, C.A.B., Camelo, S.R.P. et al. Investigation of thermal behavior of Heliotropium indicum L. lyophilized extract by TG and DSC. J Therm Anal Calorim 111, 1959–1964 (2013). https://doi.org/10.1007/s10973-011-2088-2

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  • DOI: https://doi.org/10.1007/s10973-011-2088-2

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