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Preformulation studies on grewia gum as a formulation excipient

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Abstract

Grewia gum is a naturally occurring polysaccharide which has potential as a pharmaceutical excipient. Differential scanning calorimetry and Fourier transform infrared (FT-IR) spectroscopy techniques were used to examine the thermal and molecular behaviours, respectively, of mixtures of grewia gum with cimetidine, ibuprofen or standard excipients, to assess potential interactions. No disappearance or broadening of the melting endotherm was seen with cimetidine or ibuprofen. Similarly, there was no interaction between grewia gum and the standard excipients tested. The results obtained using thermal analyses were supported by FT-IR analysis of the material mixtures. Grewia gum is an inert natural polymer which can be used alone or in combination with other excipients in the formulation of pharmaceutical dosage forms.

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References

  1. Wang Q, Cui SW. Understanding the physical properties of food polysaccharides. In: Cui SW, editor. Food carbohydrates: chemistry, physical properties, and applications. Boca Raton: Taylor & Francis; 2005. p. 162–214.

    Google Scholar 

  2. Bruni G, Berbenni V, Milanese C, Gorella A, Marini A. Drug–excipient compatibility studies on binary and ternary mixtures by physicochemical techniques. J Therm Anal Calorim. 2010;102(1):193–201.

    Article  CAS  Google Scholar 

  3. Peres-Filho MJ, Gaeti MPN, Olaveira SR, Marceto RN, Lima EM. Thermoanalytical investigation of olanzapine compatibility with excipients used in solid oral dosage forms. J Therm Anal Calorim. 2010;104(1):255–60.

    Article  Google Scholar 

  4. Brown ME, Antunes EM, Glass BD, Lebete M, Walker RB. DSC screening of potential prochloperazine–excipient interactions in preformulation studies. J Therm Anal Calorim. 1999;56:1317–22.

    Article  CAS  Google Scholar 

  5. Neto HS, Novak Cs, Matos JR. Thermal analysis and compatibility studies of prednicarbate with excipients used in semi-solid pharmaceutical form. J Therm Anal Calorim. 2009;97:367–74.

    Article  Google Scholar 

  6. Filho ROC, Franco PIBM, Conceicao EC, Leles MIG. Stability studies on nifedipine tablets using thermogravimetry and differential scanning calorimetry. J Therm Anal Calorim. 2009;97:343–7.

    Article  CAS  Google Scholar 

  7. Freire FD, Aragao CFS, Flavio Assioly de Limas Moua T, Raffin FN. Compatibility study between chlorpropamide and excipients in their physical mixtures. J Therm Anal Calorim. 2009;97:355–7.

    Article  CAS  Google Scholar 

  8. Aigner Z, Heinrich R, Sipos E, Forkas G, Ciurba A, Berkesi O, Szabo-Ravez P. Compatibility studies of aceclofenac with retard tablet excipients by means of thermal and FTIR spectroscopic methods. J Therm Anal Calorim. 2011;104(1):265–71.

    Article  CAS  Google Scholar 

  9. Gaisford S, O’Neil MAA. Role of calorimetry in preformulation studies. In: Gaisford S, editor. Pharmaceutical isothermal calorimetry. New York: Informa Healthcare Inc.; 2006:177–215

  10. Sousa e Silva JP, Sousa Lobo JM. Compatibility studies between Nevicapine, a novel COMT inhibitor, and excipients using stepwise isothermal high sensitivity DSC method. J Therm Anal Calorim. 2010;102(1):317–21.

    Article  CAS  Google Scholar 

  11. Okafor IS, Chukwu A, Udeala K. Some physicochemical properties of grewia gum. Nig J Polym Sci Technol. 2001;2(1):161–7.

    Google Scholar 

  12. Nep EI, Conway BR. Characterization of grewia gum, a potential pharmaceutical excipient. J Excip Food Chem. 2010;1(1):30–40.

    CAS  Google Scholar 

  13. Okafor IS. The rheological properties of grewia gum. Nig J Polym Sci Technol. 2001;2(1):169–76.

    Google Scholar 

  14. Nep EI, Okafor IS. Evaluation of the bioadhesive property of grewia gum in indomethacin tablet formulation in pig gastric mucus. J Pharm Bioresour. 2006;3(2):62–9.

    Google Scholar 

  15. Emeje M, Isimi C, Kunle O. Effect of grewia gum on the mechanical properties of paracetamol tablet formulations. Afr J Pharm Pharmacol. 2008;2(1):001–6.

    Google Scholar 

  16. Muazu J, Musa H, Musa KY. Compression, mechanical and release properties of paracetamol tablet containing acid treated grewia gum. J Pharm Sci Technol. 2009;1(2):74–9.

    CAS  Google Scholar 

  17. Okafor IS, Chukwu A. The mechanical properties of aqueous based grewia gum films. Nig J Polym Sci Technol. 2004;4(1):305–9.

    Google Scholar 

  18. Tita B, Fulias A, Szabadai Z, Rusu G, Bandur G, Tita D. Compatibility study between ibuprofen and excipients in their physical mixtures. doi:10.1007/s10973-010-1188-8.

  19. Bernadi LS, Oliveira PR, Murakami FS, Silva MAS, Borgmann SHM, Cardoso SG. Characterization of venlafaxine hydrochloride and compatibility studies with pharmaceutical excipients. J Therm Anal Calorim. 2009;97(2):729–33.

    Article  Google Scholar 

  20. Silverstein RM, Bassler GC, Morril TC. Spectrometric identification of organic compounds. New York: Wiley; 1991. p. 91–131.

    Google Scholar 

  21. Nunes RS, Semaan FS, Riga AT, Cavalheiro ETG. Thermal behaviour of verapamil hydrochloride and its association with excipients. J Therm Anal Calorim. 2009;97(1):349–53.

    Article  CAS  Google Scholar 

  22. Figueiro SD, Goes JC, Moreira RA, Sombra ASB. On the physicochemical and dielectric properties of glutaraldehyde cross-linked galactomannan–collagen films. Carbohydr Polym. 2004;56:313–20.

    Article  CAS  Google Scholar 

  23. Filippove MP. Practical infrared spectroscopy of pectic substances. Food Hydrocolloids. 1992;6:115–42.

    Article  Google Scholar 

  24. Xiaodong M, Marek P. Intrinsic viscosities and Huggins constants of guar gum in alkali metal chloride solutions. Carbohydr Polym. 2007;70:15–24.

    Article  Google Scholar 

  25. Wu C, McGinity JW. Influence of ibuprofen as a solid-state plasticizer in Eudragit® RS 30 D on the physicochemical properties of coated beads. AAPS PharmSciTech. 2001;2:1–9.

    Article  CAS  Google Scholar 

  26. Maheshwari M, Ketkar AR, Chauhan B, Patil VB, Paradkar AR. Preparation and characterization of ibuprofen–cetyl alcohol beads by melt solidification technique: effect of variables. Int J Pharm. 2003;261:57–67.

    Article  CAS  Google Scholar 

  27. Onoa GB, Moreno V, Freisingerb E, Lippert B. Pd(II)- and Pt(II)–cimetidine complexes. Crystal structure of trans-[Pt(N, S-cimetidine)]Cl2·12H2O. J Inorg Biochem. 2002;89:237–47.

    Article  CAS  Google Scholar 

  28. Otsuka M, Ohtani H, Kaneniwa N, Higuchi S. Isomerization of lactose in solid-state by mechanical stress during grinding. J Pharm Pharmacol. 1991;43:148–53.

    Article  CAS  Google Scholar 

  29. Drapier-Beche N, Fanni J, Parmentier M. Physical and chemical properties of molecular compounds of lactose. J Dairy Sci. 1999;82:2558–63.

    Article  CAS  Google Scholar 

  30. Ng WF, Wong MH, Cheng FT. Stearic acid coating on magnesium for enhancing corrosion resistance in Hanks’ solution. Surf Coat Technol. 2010;204:1823–30.

    Article  CAS  Google Scholar 

  31. Spoljaric S, Genovese A, Shanks RA. Polypropylene microcrystalline cellulose composites with enhanced compatibility and properties. Composites. 2009;Part A 40:791–9.

    Google Scholar 

  32. Makhija SN, Vavia PR. Once daily sustained release tablets of venlafaxine, a novel antidepressant. Eur J Pharm Biopharm. 2002;54:9–15.

    Article  CAS  Google Scholar 

  33. Bruni G, Milanese C, Berbenni V, Sartor F, Villa M, Marini A. Crystalline and amorphous phases of a new drug. J Therm Anal Calorim. 2009;102(1):297–303.

    Article  Google Scholar 

  34. Pinto MF, Afonso de Macedo E, Santos de Souza F, Macedo RO. Thermal compatibility studies of nitroimidazoles and excipients. J Therm Anal Calorim. 2010;102(1):323–9.

    Article  CAS  Google Scholar 

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Acknowledgements

Financial support for this work was provided by the Commonwealth Scholarship Commission and Aston University, Birmingham, UK.

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Author notes

  1. Elijah I. Nep

    Present address: Department of Pharmaceutics and Pharmaceutical Technology, University of Jos, Jos, Nigeria

Authors and Affiliations

  1. Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK

    Elijah I. Nep & Barbara R. Conway

  2. Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK

    Barbara R. Conway

Authors
  1. Elijah I. Nep
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  2. Barbara R. Conway
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Correspondence to Elijah I. Nep.

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Nep, E.I., Conway, B.R. Preformulation studies on grewia gum as a formulation excipient. J Therm Anal Calorim 108, 197–205 (2012). https://doi.org/10.1007/s10973-011-1782-4

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  • DOI: https://doi.org/10.1007/s10973-011-1782-4

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