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Green synthesis of CeVO4 nanoparticles using Azadirechta indica leaves extract and their promising applications as an antioxidant and anticancer agent

  • Original Paper: Nano-structured materials (particles, fibers, colloids, composites, etc.)
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Abstract

This investigation reports an eco-friendly fabrication of cerium vanadate nanoparticles (CeVO4 NPs) for the first time by an utterly green approach using Azadirachta indica leaves extract as a natural fuel. Textural properties of the as-prepared CeVO4 NPs, such as structural, topological, and optical, were explored through X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), UV-visible diffuse reflectance spectra (DRS), field-emission scanning electron microscope (FESEM), energy dispersive X-ray analysis (EDX), high-resolution transmission electron microscopy (HRTEM), and zeta potential techniques. These results indicated that the as-synthesized NPs revealed a pseudo-spherical shape with a size of 43 nm. Moreover, as-prepared NPs were subjected to anticancer performance against HeLa cancer cell lines using MTT assays. In addition, the antioxidant efficacy of biosynthesized CeVO4 NPs was scrutinized using DPPH and ABTS assays. Therefore, our study presents a facile, safe, cheap, rapid, and greener approach for producing CeVO4 NPs and opening a new door for clinical applications.

Graphical Abstract

This investigation reports an eco-benevolent fabrication of cerium vanadate nanoparticles (CeVO4 NPs) for the first time by an entirely green chemistry approach using Azadirachta indica leaves extract as a natural fuel. The physicochemical characteristics of the as-prepared CeVO4 NPs, such as structural, topological, and optical, were explored through XRD, FTIR, UV-DRS, FESEM-EDX, HRTEM, and zeta potential techniques. Moreover, as-synthesized NPs were subjected to anticancer performance against HeLa cancer cell lines and antioxidant efficacy using DPPH and ABTS assays. Therefore, our study presents a facile, safe, affordable, swift and greener approach for producing CeVO4 NPs and opening a new door for clinical applications.

Highlights

  • First-time synthesis of CeVO4 nanoparticles using Azadirachta indica leaves extract through a green chemistry approach.

  • Textural properties of CeVO4 nanoparticles were revealed through XRD, FTIR, UVDRS, FESEM, EDX-mapping, HRTEM-SAED, and zeta potential techniques.

  • The as-synthesized CeVO4 nanoparticles evinced a pseudo-spherical shape with a size of 43 nm.

  • Greenly produced CeVO4 nanoparticles exhibited excellent anticancer (HeLa cell line) and antioxidant (DPPH & ABTS assays) potentials.

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Authors and Affiliations

  1. Department of Chemistry, S.N. Arts, D.J.M. Commerce & B.N.S. Science College (Autonomous), Savitribai Phule Pune University, Sangamner, 422 605, Maharashtra, India

    Suresh Ghotekar & Rajeshwari Oza

  2. Department of Chemistry, Smt. Devkiba Mohansinhji Chauhan College of Commerce & Science (University of Mumbai), UT of DD & DNH, Silvassa, 396 230, India

    Suresh Ghotekar

  3. Department of Chemistry, Sikkim Institute of Science & Technology, Sikkim University, Sikkim, India

    Parita Basnet

  4. Department of Environmental Engineering & Innovation and Development Center of Sustainable Agriculture, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung, Taiwan

    Kun-Yi Andrew Lin

  5. Department of Physics, Faculty of Science, University of Zabol, Zabol, P.O. Box. 35856-98613, Iran

    Abbas Rahdar

  6. Research Laboratory in Nanomaterials, Water and Energy, Engineering Department, University of Guadalajara, Campus Los Altos, Tepatitlán de Morelos, 47600, Jalisco, Mexico

    Alejandro Pérez Larios

  7. Department of Chemical Engineering, Dharmsinh Desai University, Nadiad, 387 001, Gujarat, India

    Vimal Gandhi

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  1. Suresh Ghotekar
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  2. Parita Basnet
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Correspondence to Suresh Ghotekar or Rajeshwari Oza.

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Ghotekar, S., Basnet, P., Lin, KY.A. et al. Green synthesis of CeVO4 nanoparticles using Azadirechta indica leaves extract and their promising applications as an antioxidant and anticancer agent. J Sol-Gel Sci Technol 106, 726–736 (2023). https://doi.org/10.1007/s10971-023-06105-x

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