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Synthesis, chemical characterization and radiological response of Ho and HoZr bioglass seeds

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Abstract

This work aims to study the synthesis and characterization of Ho and HoZr bioglass seeds, in addition to radiological response with the contrast agent Zr incorporated. The cylindrical seeds, identified also as [Si:Ca:Ho] and [Si:Ca:Ho:Zr], were synthesized by the sol–gel method and coated with acrylic resin and polyvinyl alcohol membrane . Analysis of the mass attenuation coefficients of Ho and Zr according to the medical X-ray spectrum was performed. The synthesized bioglasses were characterized by quantitatively and qualitatively evaluating the main elemental composition. The following characterization techniques were performed: UV–Vis spectrometry, energy-dispersive X-ray fluorescence (EDS) and X-ray fluorescence with CdTe detector and americium excitation source (Am-241). As results, seeds were synthesized and coated within the two established dimensions of 0.35 ± 0.05 and 0.65 ± 0.05 mm diameters and 1.50 ± 0.10 and 1.57 ± 0.05 mm lengths. The Ho composition was 30.7 % and Zr 22.2 % on [Si:Ca:Ho:Zr] seeds. The mass attenuation coefficient of zirconium showed to be eightfold superior to the holmium within the medical diagnosis spectra. Radiological response of [Si:Ca:Ho:Zr] seeds showed 20 % higher contrast compared to [Si:Ca:Ho], within a background equivalent to breast glandular tissue, resulting in an appropriate radiological visibility of [Si:Ca:Ho:Zr]. As conclusion, the characterization methods have identified their elemental composition. Insertion of Zr in the synthesis has increased the radiological contrast, allowing implant’s monitoring by conventional X-ray or mammogram.

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Acknowledgments

The authors are thankful to the Microscopy Center of the Universidade Federal de Minas Gerais (UFMG) and the “Conselho Nacional de Pesquisa Cientifica e Tecnologica”—CNPq Process No. 456719/2013-0, Call 57/2013 MCTI/CNPq/MS—SCTIE—DECIT—“Rede Brasileira de Avaliação de Tecnologias em Saúde: Pesquisa de Efetividade Comparativa” (PEC-REBRATS).

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Authors and Affiliations

  1. Anatomy and Imaging Department, Federal University of Minas Gerais, 190 Alfredo Balena Avenue, Belo Horizonte, 30130100, Brazil

    Luciana Batista Nogueira

  2. Nuclear Engineering Department, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Tarcísio Passos Ribeiro Campos

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  1. Luciana Batista Nogueira
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  2. Tarcísio Passos Ribeiro Campos
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Correspondence to Luciana Batista Nogueira.

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Nogueira, L.B., Campos, T.P.R. Synthesis, chemical characterization and radiological response of Ho and HoZr bioglass seeds. J Sol-Gel Sci Technol 77, 688–698 (2016). https://doi.org/10.1007/s10971-015-3900-4

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  • DOI: https://doi.org/10.1007/s10971-015-3900-4

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