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A pH-sensitive controlled dual-drug release from meso-macroporous silica/multilayer-polyelectrolytes coated SBA-15 composites

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Abstract

A novel dual-drug delivery system based on mesoporous-macroporous silica/polyelectrolytes-SBA-15 has been synthesized. The structure and composition of these materials were characterized by powder X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and N2 adsorption–desorption measurements. In this system, water-soluble metformin hydrochloride and fat-soluble ibuprofen were used as model drugs to study the controlled release behavior. The pH-controlled release of individual drugs was obtained by the primary release of metformin hydrochloride from polyelectrolytes-SBA-15 in acid condition and the predominant release of ibuprofen from MMC in alkaline environment. The results show that the polyelectrolytes-SBA-15/mesoporous-macroporous silica can be used as dual-drug release system and the individual drug can be controlled release with the change of pH value of the environment.

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Acknowledgments

Financial support for this study was provided by the National Natural Science Foundation of China (21171045, 21101046), Natural Science Foundation of Heilongjiang Province of China (ZD201214, B201206), Program for Scientific and Technological Innovation team Construction in Universities of Heilongjiang province (2011TD010), Research Fund for the Doctoral Program of Higher Education of China (20102329110002), Foundation of Harbin Educational Committee (12521164).

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Authors and Affiliations

  1. Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education,College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, People’s Republic of China

    Qumei Jin, Fengyu Qu, Jingjie Jiang, Yan Dong, Wei Guo & Huiming Lin

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  1. Qumei Jin
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  2. Fengyu Qu
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  3. Jingjie Jiang
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  4. Yan Dong
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  5. Wei Guo
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  6. Huiming Lin
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Correspondence to Jingjie Jiang or Huiming Lin.

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Jin, Q., Qu, F., Jiang, J. et al. A pH-sensitive controlled dual-drug release from meso-macroporous silica/multilayer-polyelectrolytes coated SBA-15 composites. J Sol-Gel Sci Technol 66, 466–471 (2013). https://doi.org/10.1007/s10971-013-3033-6

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  • DOI: https://doi.org/10.1007/s10971-013-3033-6

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