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Biodistribution and toxicity assessment of radiolabeled and DMSA coated ferrite nanoparticles in mice

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Abstract

DMSA-coated Fe3O4 nanoparticles were synthesized by wet-chemical method. The chemical interaction between Fe3O4 and DMSA were investigated by FTIR. They were directly radiolabeled with 99mTc radioisotope (Fe3O4@DMSA–99mTc) at room temperature in the presence of stannous solution as a reducing agent. Magnetic and structure properties of Fe3O4@DMSA–99mTc nanoparticles were investigated by AGFM, TEM, and XRD. Biodistribution and toxicity assessment of Fe3O4@DMSA–99mTc were studied in mice by intravenous and intraperitoneally injections, respectively. Blood, kidney, and liver factors were measured 4 days post injection and at the mean-while tissue sections were prepared from their kidney and liver. The results indicate that, the Fe3O4@DMSA–99mTc nanoparticles were passed through the membrane of different cells but do not create any disorder in the kidney and liver function even in high doses such as 300 mg/kg.

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Acknowledgments

The authors are grateful from Department of Biology, Faculty of Basic Sciences, Falavarjan Islamic Azad University for their cooperation and supplying the experimental equipments (Most experimental results are from research code No. 301/2811).

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Authors and Affiliations

  1. Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    S. Fatahian & M. Pouladian

  2. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    D. Shahbazi-Gahrouei

  3. Department of Sciences, Nano-Center, Malek-Ashtar University of Technology, Shahin-Shahr, P.O. Box 83145/115, Isfahan, Iran

    M. H. Yousefi

  4. Falavarjan Branch, Islamic Azad University, Isfahan, Iran

    Gh. R. Amiri & A. Noori

Authors
  1. S. Fatahian
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  2. D. Shahbazi-Gahrouei
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  3. M. Pouladian
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  4. M. H. Yousefi
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  5. Gh. R. Amiri
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  6. A. Noori
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Correspondence to S. Fatahian.

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Fatahian, S., Shahbazi-Gahrouei, D., Pouladian, M. et al. Biodistribution and toxicity assessment of radiolabeled and DMSA coated ferrite nanoparticles in mice. J Radioanal Nucl Chem 293, 915–921 (2012). https://doi.org/10.1007/s10967-012-1822-y

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  • DOI: https://doi.org/10.1007/s10967-012-1822-y

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