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Study of the cyclotron production of 172Lu: an excellent radiotracer

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Abstract

172Lu due to its suitable (T1/2 = 6.7 days) and high detection sensitivity, is used as a radiotracer in different fields. 172Lu appears to be suitable as a long-lived rare-earth tracer for compound labelling and biodistribution studies. In the present study, excitation functions via 172Yb(p,n)172Lu, natYb(p,xn)172Lu, 172Yb(d,2n)172Lu and natYb(d,xn)172Lu reactions were calculated by ALICE/91, ALICE/ASH and TALYS-1.2 codes. Deposition of natYb2O3 on Cu substrate was carried out via sedimentation method for the production of 172Lu. Cementation separation process and liquid–liquid extraction (LLX) of no-carrier-added (nca) radiolutetium from irradiated ytterbium(III)oxide target hydrochloric solution was described using Na(Hg) amalgam, α-hydroxyisobutyric acid (α-HIB) and di-(2-ethylhexyl)phosphoric acid (HDEHP).

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Authors and Affiliations

  1. Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, P.O. Box 31485/498, Karaj, Tehran, Iran

    Mahdi Sadeghi

  2. Faculty of Engineering, Research and Science Branch, Islamic Azad University, Tehran, Iran

    Milad Enferadi & Hojjat Nadi

Authors
  1. Mahdi Sadeghi
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  2. Milad Enferadi
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  3. Hojjat Nadi
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Correspondence to Mahdi Sadeghi.

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Sadeghi, M., Enferadi, M. & Nadi, H. Study of the cyclotron production of 172Lu: an excellent radiotracer. J Radioanal Nucl Chem 286, 259–263 (2010). https://doi.org/10.1007/s10967-010-0649-7

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  • DOI: https://doi.org/10.1007/s10967-010-0649-7

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