Skip to main content
Log in

Spatial regression analysis between air pollution and childhood leukaemia in Portugal

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

This study aims to investigate whether known carcinogenic chemical elements in atmospheric deposition might be associated with child mortality due to leukemia in the Portuguese population. A Bayesian hierarchical model was used to explore the association between lichen biomonitoring measurements of four elements—As, Hg, Ni, Pb—and childhood leukemia death counts taken at small administrative units. This geographical epidemiological study found a non-significant positive association between the risk of childhood leukemia and levels of arsenic, mercury and lead, and a non-significant negative association between the disease and the level of nickel. Lead seems to show a weaker association with childhood leukemia than arsenic and mercury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. IARC Working Group. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, vol. 23, Suppl. 7 (1987)

  2. IARC Working Group. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, vol. 49 (1990)

  3. Baird, C.: Toxic Organic Chemicals. In: W.H. Freeman and Company (ed.) Environmental Chemistry. W.H. Freeman and Company, NY, USA (1995)

  4. Bowen, H.J.M.: Environmental Chemistry of the Elements. Academic Press, London (1979)

    Google Scholar 

  5. Best, N., Cockings, S., Bennett, J., Wakefield, J., Elliot, P.: Ecological regression analysis of environmental benzene exposure and childhood leukemia: sensitivity to data inaccuracies, geographical scale and ecological bias. J. R. Stat. Soc. A 164, 155–174 (2001)

    Article  Google Scholar 

  6. Raaschou-Nielsen, O., Hertel, O., Thomsen, B.L., Olsen, J.H.: Air pollution from traffic at the residence of children with cancer. Am. J. Epidemiol. 153, 433–443 (2001)

    Article  CAS  Google Scholar 

  7. Wolterbeek, H.T., Garty, J., Reis, M.A., Freitas, M.C.: Biomonitors in use: lichens and metal air pollution. In: Markert, B.A., Breure, A.M., Zechmeister, A.G. (eds.) Bioindicators and Biomonitors, pp. 377–419. Elsevier Science B.V., Amsterdam, The Netherlands (2002)

    Google Scholar 

  8. Wolterbeek, H.T.: Biomonitoring of trace element air pollution: principles, possibilities and perspectives. Environmental pollution. Environ. Poll. 120, 11–21 (2002)

    Article  CAS  Google Scholar 

  9. Bargagli, R.: Lichens as biomonitors of airborne trace elements. In: Trace Elements in Terrestrial Plants: An Ecophysiological Approach to Biomonitoring and Biorecovery, pp. 179–206. Springer, Berlin, Germany, (1998)

  10. Reis, M.A., Alves, L.C., Wolterbeek, H.T., Verburg, T., Freitas, M.C., Gouveia, A.: Main atmospheric heavy metal sources in Portugal by biomonitor analysis. Nucl. Instr. Meth. Phys. Res. B 109/110, 493–497 (1996)

    Article  CAS  Google Scholar 

  11. Freitas, M.C., Reis, M.A., Alves, L.C., Wolterbeek, H.T., Verburg, T., Gouveia, A.: Biomonitoring of trace-element air pollution in Portugal: qualitative survey. J. Radioanal. Nucl. Chem. 217, 21–30 (1997)

    Article  CAS  Google Scholar 

  12. Freitas, M.C., Reis, M.A., Alves, L.C., Wolterbeek, H.T.: Distribution in Portugal of some pollutants in the lichen Parmelia sulcata. Environ. Poll. 106, 229–235 (1999)

    Article  CAS  Google Scholar 

  13. Reis, M.A.: Biomonitoring and assessment of atmospheric trace elements in Portugal. Methods, response modeling and nuclear analytical techniques. Ph.D. Thesis, Technical University of Delft, The Netherlands (2001)

  14. Freitas, M.C., Reis, M.A., Alves, L.C., Wolterbeek, H.T.: Nuclear analytical techniques in atmospheric trace element studies in Portugal. In: Markert, B.A., Friese, K. (eds.) Trace Elements—Their Distribution, Effects in the Environment, pp. 187–213. Elsevier, Amsterdam, The Netherlands (2000)

    Google Scholar 

  15. Freitas, M.C., Nobre, A.S.: Bioaccumulation of heavy metals using Parmelia sulcata and Parmelia caperata for air pollution studies. J. Radioanal. Nucl. Chem. 217, 17–20 (1997)

    Article  CAS  Google Scholar 

  16. Sarmento, S., Wolterbeek, H.T., Verburg, T.G., Freitas, M.C.: Correlating element atmospheric deposition and cancer mortality in Portugal: data handling and preliminary results. Environ. Poll. 151, 341–351 (2008)

    Article  CAS  Google Scholar 

  17. Diggle, P.J., Moyeed, R.A.: Model-based geostatistics. Appl. Statist. 47, 299–350 (1998)

    Google Scholar 

  18. Estève, J., Benhamou, E., Raymond, L.: Statistical Methods in Cancer Research, vol. IV—Descriptive Epidemiology, International Agency for Research on Cancer (1994)

  19. Besag, J., York, J., Mollié, A.: Bayesian image restoration with two applications in spatial statistics. Ann. Inst. Statist. Math. 43, 1–59 (1991)

    Article  Google Scholar 

  20. Cliff, A.D., Ord, J.K.: Spatial Processes: Models and Applications. Pion, London (1981)

    Google Scholar 

  21. Thomas, A., Best, N., Lunn, D., Arnold, R., Spiegelhalter, D.: GeoBUGS User Manual, Version 1.2 (2004). http://www.mrc-bsu.cam.ac.uk/bugs/

  22. Freitas, M.C., Farinha, M.M., Ventura, M.G., Almeida, S.M., Reis, M.A., Pacheco, A.M.G.: Gravimetric and chemical features of airborne PM10 and PM2.5 in mainland Portugal. Environ. Monit. Assess. 109, 81–95 (2005)

    Article  CAS  Google Scholar 

  23. Pio, C.A., Ramos, M.R., Duarte, A.C.: Atmospheric aerosol and soiling of external surfaces in an urban environment. Atmos. Environ. 32, 1979–1989 (1998)

    Article  CAS  Google Scholar 

  24. Portuguese Environment Agency, Portuguese Ministry of Environment (2006). http://www.apambiente.pt

  25. Greenland, S., Morgenstern, H.: Ecological bias, confounding, and effect modification. Int. J. Epidemiol. 18, 269–274 (1989)

    Article  CAS  Google Scholar 

  26. Wolterbeek, H.T., Verburg, T.G.: Judging survey quality in biomonitoring. In: Wiersma, G.B. (ed.) Environment Monitoring, pp. 583–604. CRC Press, Boca Raton, FL (2004)

    Google Scholar 

  27. Robinson, W.: Ecological correlations and the behavior of individuals. Am. Sociol. Rev. 15, 351–357 (1950)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. C. Freitas.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Martinho, M., Freitas, M.C. Spatial regression analysis between air pollution and childhood leukaemia in Portugal. J Radioanal Nucl Chem 281, 175–179 (2009). https://doi.org/10.1007/s10967-009-0124-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-009-0124-5

Keywords

Navigation