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Paper radiochromatography for evaluation of radiochemical purity and stability of [186gRe]Re-HEDP in biological samples after human administration

  • Radiotracers in Chemical-Technological Research
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Abstract

[186gRe]Re-HEDP is a radiopharmaceutical used for pain palliation in bone metastases from various primary tumors. The negatron emitter with 〈E β 〉 = 357 keV 186gRe is suitable to irradiate cancer and inflammatory cells, but it needs labeling bis-phosphonates as vectors to reach target tissue. Paper radiochromatography was used to evaluate the radiochemical purity of [186gRe]Re-HEDP in radiopharmaceutical solution as well as in biological samples (serum and urine) from treated patients, in order to follow bone-targeting and excretion. Following the activity concentration in each sample vs. time it is effective to elaborate a bio-kinetic model of the radiopharmaceutical and to optimize administration protocols.

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Authors and Affiliations

  1. Italian National Agency for New Technologies, Energy and the Environment, ENEA, Research Centre of Saluggia, Radiation Protection Institute, Strada per Crescentino 41, I-13040, Saluggia (VC), Italy

    S. Ridone

  2. LASA, Università degli Studi and INFN of Milano, Radiochemistry Laboratory, via F.lli Cervi, 201, I-2000, Segrate (MI), Italy

    S. Ridone, M. L. Bonardi, F. Groppi & A. Martinotti

  3. Department of Nuclear Engineering, Ben Gurion University Negev, Il-84105, Beer Sheva, Israel

    Z. B. Alfassi

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  1. S. Ridone
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  2. M. L. Bonardi
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  3. F. Groppi
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  4. A. Martinotti
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  5. Z. B. Alfassi
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Correspondence to S. Ridone.

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Ridone, S., Bonardi, M.L., Groppi, F. et al. Paper radiochromatography for evaluation of radiochemical purity and stability of [186gRe]Re-HEDP in biological samples after human administration. J Radioanal Nucl Chem 277, 117–123 (2008). https://doi.org/10.1007/s10967-008-0718-3

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  • DOI: https://doi.org/10.1007/s10967-008-0718-3

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