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Graphene quantum dots coated cationic polymer for targeted drug delivery and imaging of breast cancer

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Abstract

One of the important goals of cancer treatment in drug delivery systems (DSS) is to increase the concentration of the drug only around the tumor cells to prevent damage to normal cells. In this study, doxorubicin (DOX) was imprinted by the cationic polymer; Poly (methacrylic acid-co-diallyldimethylammonium chloride) PMA DDA coated-GQDs. Chemical structure PMA DDA-coated GQDs was investigated and confirmed by using Fourier-transform infrared spectroscopy (FT-IR). Particle size and morphology of PMA DDA-coated GQDs was evaluated by Field Emission Scanning Electron Microscope (FE-SEM). Then the toxicity of PMA DDA-coated GQDs was investigated in vitro study. Also to evaluate the effectiveness of PMA DDA-coated GQDs in the living organism, Nanoparticles were injected into BALB/C mice containing 4T1 breast cancer cells. Then in vivo imaging was performed at the excitation wavelength of 400 nm and emission of 535 nm. The images showed that particles PMA DDA-coated GQDs had accumulated around the cancer cell.

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The data are available from the corresponding author upon sensible request.

References

  1. Fleege NMG, Cobain EF (2022) Breast cancer management in 2021: a primer for the OB GYN. Best Pract Res Clin Obstet Gynaecol

  2. Chiang JCB, Zahari I, Markoulli M, Krishnan AV, Park SB, Semmler A, Goldstein D, Edwards K (2020) The impact of anticancer drugs on the ocular surface. Ocul Surf 18(3):403–417

    Article  PubMed  Google Scholar 

  3. Sahu T, Ratre YK, Chauhan S, Bhaskar L, Nair MP, Verma HK (2021) Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science. J Drug Deliv Sci Technol 63:102487

  4. Dhup S, Kumar Dadhich R, Ettore Porporato P, Sonveaux P (2012) Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr Pharm Des 18(10):1319–1330

  5. Chen B, Le W, Wang Y, Li Z, Wang D, Ren L, Lin L, Cui S, Hu JJ, Hu Y (2016) Targeting negative surface charges of cancer cells by multifunctional nanoprobes. Theranostics 6(11):1887

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Samal SK, Dash M, Van Vlierberghe S, Kaplan DL, Chiellini E, Van Blitterswijk C, Moroni L, Dubruel P (2012) Cationic polymers and their therapeutic potential. Chem Soc Rev 41(21):7147–7194

    Article  CAS  PubMed  Google Scholar 

  7. Farhad-Gholami N, Hashemi-Moghaddam H, Shaabanzadeh M, Zavareh S, Madanchi H (2021) Sustained doxorubicin delivery system to breast tumor cancer cell based on a novel cationic molecularly imprinted polymer. Int J Polym Mater Polym Biomater 1–10

  8. Gidwani B, Sahu V, Shukla SS, Pandey R, Joshi V, Jain VK, Vyas A (2021) Quantum dots: Prospectives, toxicity, advances and applications. J Drug Deliv Sci Technol 61:102308

  9. Patel V, Shah J, Gupta AK (2021) Design and In-silico study of bioimaging fluorescence Graphene quantum dot-Bovine serum albumin complex synthesized by diimide-activated amidation. Comput Biol Chem 93:107543

  10. Chung S, Revia RA, Zhang M (2021) Graphene quantum dots and their applications in bioimaging, biosensing, and therapy. Adv Mater 33(22):1904362

    Article  CAS  Google Scholar 

  11. Sohal N, Maity B, Basu S (2021) Recent advances in heteroatom-doped graphene quantum dots for sensing applications. RSC Adv 11(41):25586–25615

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ghaffarkhah A, Hosseini E, Kamkar M, Sehat AA, Dordanihaghighi S, Allahbakhsh A, van der Kuur C, Arjmand M (2022) Synthesis, applications, and prospects of graphene quantum dots: a comprehensive review. Small 18(2):2102683

    Article  CAS  Google Scholar 

  13. Masteri-Farahani M, Mashhadi-Ramezani S, Mosleh N (2020) Molecularly imprinted polymer containing fluorescent graphene quantum dots as a new fluorescent nanosensor for detection of methamphetamine. Spectrochim Acta A Mol Biomol Spectrosc 229:118021

  14. Shi W, Sahoo Y, Swihart M (2008) Colloids and surfaces a: physicochem. Eng Aspects 320:92

    Google Scholar 

  15. Mirzababaei M, Larijani K, Hashemi-Moghaddam H, Mirjafary Z, Madanchi H (2021) In vitro targeting of NL2 peptide bounded on poly L-DOPA coated graphene quantum dot. J Fluoresc 31(1):279–288

    Article  CAS  PubMed  Google Scholar 

  16. Maghsood F, Johari B, Rohani M, Madanchi H, Saltanatpour Z, Kadivar M (2020) Anti-proliferative and anti-metastatic potential of high molecular weight secretory molecules from probiotic Lactobacillus reuteri cell-free supernatant against human colon cancer stem-like cells (HT29-ShE). Int J Pept Res Ther 26(4):2619–2631

    Article  CAS  Google Scholar 

  17. Madanchi H, Khalaj V, Jang S, Shabani AA, Ebrahimi Kiasari R, Seyed Mousavi SJ, Kazemi Sealani S, Sardari S (2019) AurH1: a new heptapeptide derived from Aurein1. 2 antimicrobial peptide with specific and exclusive fungicidal activity. J Pept Sci 25(7):e3175

  18. Kalluri A, Debnath D, Dharmadhikari B, Patra P (2018) Graphene quantum dots: Synthesis and applications, Methods in enzymology. Elsevier 335–354

  19. Sun W, Liu W-L, Hu Y-H (2008) FTIR analysis of adsorption of poly diallyl-dimethyl-ammonium chloride on kaolinite. J Cent South Univ Technol 15(3):373–377

    Article  CAS  Google Scholar 

  20. Dang Y, Guan J (2020) Nanoparticle-based drug delivery systems for cancer therapy. Smart Mater Med 1:10–19

    Article  PubMed  PubMed Central  Google Scholar 

  21. Jeannot V, Gauche C, Mazzaferro S, Couvet M, Vanwonterghem L, Henry M, Didier C, Vollaire J, Josserand V, Coll J-L (2018) Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer. J Control Release 275:117–128

    Article  CAS  PubMed  Google Scholar 

  22. Sun Y, Ma X, Hu H (2021) Application of nano-drug delivery system based on cascade technology in cancer treatment. Int J Mol Sci 22(11):5698

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. de Castilla PEM, Tong L, Huang C, Sofias AM, Pastorin G, Chen X, Storm G, Schiffelers RM, Wang J-W (2021) Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies. Adv Drug Deliv Rev 175:113801

  24. Chadar R, Afzal O, Alqahtani SM, Kesharwani P (2021) Carbon nanotubes as an emerging nanocarrier for the delivery of doxorubicin for improved chemotherapy. Colloids Surf B Biointerfaces 208:112044

  25. Wei C, Dong X, Zhang Y, Liang J, Yang A, Zhu D, Liu T, Kong D, Lv F (2018) Simultaneous fluorescence imaging monitoring of the programmed release of dual drugs from a hydrogel-carbon nanotube delivery system. Sens Actuators B Chem 273:264–275

    Article  CAS  Google Scholar 

  26. Le W, Chen B, Cui Z, Liu Z, Shi D (2019) Detection of cancer cells based on glycolytic-regulated surface electrical charges. Biophys Rep 5(1):10–18

    Article  CAS  Google Scholar 

  27. Hashemzadeh H, Raissi H (2020) Understanding loading, diffusion and releasing of doxorubicin and paclitaxel dual delivery in graphene and graphene oxide carriers as highly efficient drug delivery systems. Appl Surf Sci 500:144220

  28. Kayal S, Ramanujan R (2010) Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery. Mater Sci Eng C 30(3):484–490

    Article  CAS  Google Scholar 

  29. He J, Li C, Ding L, Huang Y, Yin X, Zhang J, Zhang J, Yao C, Liang M, Pirraco RP (2019) Tumor targeting strategies of smart fluorescent nanoparticles and their applications in cancer diagnosis and treatment. Adv Mater 31(40):1902409

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mahdi Mirzababaei, Kambiz Larijani & Zohreh Mirjafary

  2. Departments of Medicinal Chemistry, School of Pharmacy, Damghan Branch, Islamic Azad University, Damghan, Iran

    Hamid Hashemi-Moghaddam

  3. Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

    Hamid Madanchi

  4. Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

    Hamid Madanchi

Authors
  1. Mahdi Mirzababaei
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  2. Kambiz Larijani
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  3. Hamid Hashemi-Moghaddam
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  4. Zohreh Mirjafary
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  5. Hamid Madanchi
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Correspondence to Hamid Hashemi-Moghaddam.

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Mirzababaei, M., Larijani, K., Hashemi-Moghaddam, H. et al. Graphene quantum dots coated cationic polymer for targeted drug delivery and imaging of breast cancer. J Polym Res 30, 268 (2023). https://doi.org/10.1007/s10965-023-03638-1

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  • DOI: https://doi.org/10.1007/s10965-023-03638-1

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