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Thermosensitive PCEC hydrogel loaded with carbon nanotubes for slow-release lubrication effect

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Abstract

Injectable hydrogel provides a new advance on lubrication of artificial joints due to its in situ forming property and long-term release effect. The adaptability improvement of the injectable hydrogel is crucial for its successful application in joint prostheses without weakening its injectable performance. In this paper, we reported a thermosensitive poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCEC) hydrogel embedded with carbon nanotubes (CNT) to improve its shear resistance and strain resistance. The phase-transition test demonstrated that the temperature range at the gel state for the PCEC/CNT hydrogel is higher than that of PCEC hydrogel under identical condition. We also demonstrated the CNT enhance the viscoelasticity of the thermosensitive PCEC hydrogel under the premise of retaining the effective slow-release behavior of bull serum albumin. The PCEC/CNT composite hydrogel has excellent slow-release and release-lubrication effects while maintaining its injectability. Consequently, it shows a promising application prospect as an injectable carrier, which provides slow-release lubrication effect on artificial joints.

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Funding

This work was supported by Special Research Project in Shaanxi Province Department of Education (20JK0668); The Project National United Engineering Laboratory for Advanced Bearing Tribology (202106); Science and Technology on Diesel Engine Turbocharging Laboratory (6142212190104) and Innovation Capability Support Program of Shaanxi (2020KJXX-016).

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Authors and Affiliations

  1. School of Mechatronic Engineering, Xi’an Technological University, Xi’an, 710021, China

    Junde Guo, Geng Zhang, Runling Peng, Yan Cao & Hao Dong

  2. National United Engineering Laboratory for Advanced Bearing Tribology, Henan University of Science and Technology, Luoyang, 471000, China

    Junde Guo

  3. Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System, Xi’an Jiaotong University, Xi’an 710049, China

    Hui Zhang

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  1. Junde Guo
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  2. Geng Zhang
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  3. Runling Peng
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  4. Yan Cao
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  6. Hui Zhang
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Correspondence to Junde Guo.

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Guo, J., Zhang, G., Peng, R. et al. Thermosensitive PCEC hydrogel loaded with carbon nanotubes for slow-release lubrication effect. J Polym Res 28, 239 (2021). https://doi.org/10.1007/s10965-021-02610-1

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