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Blends of synthetic plastic-derived polypeptide with Hydroxypropylmethylcellulose and polyvinyl alcohol: unraveling the specific interaction parameters, morphology and thermal stability of the polymers couple

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Abstract

The medleys of the plastic-derived polypeptide with commercially available polymers believably the suitable candidate for pharmaceutical and biomedical importance. The current research is focussed on the synthesis of a novel plastic-mimetic polypeptide (PLP), poly(IPAVG) by the solution phase method (where I, P, A, V, and G represent Isoleucine, Proline, Alanine, Valine, and Glycine, respectively). The miscibility attributes of PLP/polyvinyl alcohol (PVA) and PLP/hydroxypropylmethylcellulose (HPMC) blends were examined by viscometry and by other advanced analytical tools for different weight proportions. It is shown by the viscometry that the PLP/HPMC and PLP/PVA form an immiscible blend system at 10 οC and further, the FTIR spectra of poly (IPAVG) /HPMC and poly (IPAVG) /PVA blend membranes manifest the lack of intermolecular interactions. DSC results proved the dual Tg for one blend proportion and lower Tg values for all other blend systems. The thermal property of the blends with different compositions was evaluated by thermogravimetric analysis (TGA). The TGA results showed that the blends possess inferior thermal stability to the native ones. The surface morphology was analyzed by SEM indicated the heterogeneity and X-ray diffraction (XRD) revealed the absence of any change in crystallinity advocated the immiscibility of the blends. Further, we ventured to prepare the non-woven fabrics from the solutions of 1–10 wt% concentrations at the voltages within 20–30 kV by electrospinning. The droplet formed at the spinneret failed to reach the collector plate, and consequently, no films developed for the collector device.

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Acknowledgements

We acknowledge the financial assistance from 1) Vision Group on Science and Technology; Department of IT, BT and S and T; Government of Karnataka, INDIA under CISEE scheme: Ref: No. VGST/CISEE/GRD326/2014-15(2015-16) 2) Administration of JSS Mahavidyapeetha, Mysuru, Principal, JSSATE, Bengaluru for the amenities and motivating and 3) also grateful to Mr. Nanjundaswamy GS for his suitable help while preparing the document.

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Authors and Affiliations

  1. Department of Chemistry, JSS Academy of Technical Education ( Affiliated to Visvesvaraya Technological University, Belagavi), Dr.Vishnuvardhan Road, Bengaluru, 560060, India

    B Mahesh & D Kathyayani

  2. Department of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, 570 006, India

    D Channe Gowda

  3. Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, 570 015, India

    K Mrutunjaya

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  1. B Mahesh
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Correspondence to B Mahesh.

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Mahesh, B., Kathyayani, D., Channe Gowda, D. et al. Blends of synthetic plastic-derived polypeptide with Hydroxypropylmethylcellulose and polyvinyl alcohol: unraveling the specific interaction parameters, morphology and thermal stability of the polymers couple. J Polym Res 27, 278 (2020). https://doi.org/10.1007/s10965-020-02191-5

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