Abstract
Sodium alginate grafted stearic acid (NaAlg-g-St) was synthesized via the reaction of stearic acid and sodium alginate (NaAlg) in the presence of diisopropylcarbodiimid (DIC) under the solvent free condition. Sustained release matrix tablets of indomethacin (IM) were developed by employing sodium alginate or the new synthesized polymer. The drug dissolution test and other physicochemical properties were evaluated for each formulation. The results of this study showed that sodium alginate grafted stearic acid, has a good effect on the sustained releasing feature of the tablets and causes the drug to be released gradually; and probably, causes less side effects and more compliance in patients. In the physicochemical tests, the usage of NaAlg or the NaAlg-g-St was not effective on the tablet’s hardness but in other tests made a significant change statistically.
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References
Lendlein A, Sisson A (2011) Handbook of biodegradable polymers: isolation, synthesis, characterization and applications. John Wiley & Sons, Hoboken
Ottenbrite RM, Kim SW (2019) Polymeric drugs and drug delivery systems. CRC Press, Boca Raton
Kang Y, Wang C, Qiao Y et al (2019). Biomacromolecules 20:1765–1776
Zhao W, Li J, Jin K et al (2016). Mater Sci Eng C 59:1181–1194
Bachelder EM, Pino EN, Ainslie KM (2016). Chem Rev 117:1915–1926
Hu Y, Peng J, Ke L et al (2016). J Polym Res 23:129
Rodrigues D, Freitas AC, Pereira L et al (2015). Food Chem 183:197–207
Abedini F, Ebrahimi M, Roozbehani AH et al (2018). Polym Adv Technol 29:2564–2573
Hu Y, Zhang S, Han D et al (2018). J Polym Res 25:148
Akın A, Işıklan N (2016). Int J Biol Macromol 82:530–540
Kumar D, Pandey J, Raj V et al (2017). Open Med Chem J 11:109
Ali U, KJBA K, Buang NA (2015). Polym Rev 55:678–705
Işıklan N, Küçükbalcı G (2012). Eur J Pharm Biopharm 82:316–331
Ramesh KS (2015). Asian J Pharm 9:234–242
Brunton LL (2014) Goodman and Gilman's manual of pharmacology and therapeutics. McGraw-Hill, New York
Horibe S, Tanahashi T, Kawauchi S et al (2016). Int J Med Sci 13:653–663
Nawale R, Mohite K (2013). Int J Pharm Sci Res 4:3670–3677
Pharmacopeia U (2014) Rockville: US Pharmacopeia
Işıklan N, Kurşun F, İnal M (2010). Carbohydrate polym 79:665–672
Varshosaz J, Hassanzadeh F, Sadeghi H et al (2012). J Nanomater 2012 Article ID:265657
Varshosaz J, Hassanzadeh F, Sadeghi-Aliabadi H et al (2014). BioMed Res Int 2014 Article ID:708593
Anwar H, Ahmad M, Minhas MU et al (2017). Carbohydr Polym 166:183–194
Youssouf L, Lallemand L, Giraud P et al (2017). Carbohydr Polym 166:55–63
Elsayed NH, Monier M, RAS A (2016). Carbohydr Polym 145:121–131
Badri W, Miladi K, Robin S et al (2017). Pharm Res 34:1773–1783
Padrela L, Rodrigues MA, Velaga SP et al (2009). Eur J Pharm Sci 38:9–17
Choudhary S, Reck JM, Carr AJ et al (2018). Polym Adv Technol 29:198–204
Yang J, Dong H (2016). Carbohydr Polym 153:1–6
Marounek M, Volek Z, Taubner T et al (2019). Int J Biol Macromol 122:499–502
Taubner T, Marounek M, Synytsya A (2017). Int J Biol Macromol 103:202–207
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The authors wish to acknowledge financial support for this work by the deputy of research, Hamadan University of Medical Sciences (Grant number: 960115172).
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Chehardoli, G., Bagheri, H. & Firozian, F. Synthesis of sodium alginate grafted stearate acid (NaAlg-g-St) and evaluation of the polymer as drug release controlling matrix. J Polym Res 26, 175 (2019). https://doi.org/10.1007/s10965-019-1840-3
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DOI: https://doi.org/10.1007/s10965-019-1840-3