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Mixed Ligand Complex Formation Reactions and Equilibrium Studies of Cu(II) with Bidentate Heterocyclic Alcohol (N,O) and Some Bio-Relevant Ligands

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Abstract

The formation equilibria of copper(II) complexes and the ternary complexes Cu(HMI)L (HMI=4-Hydroxymethyl-imidazole, L=amino acid, amides or DNA constituents) have been investigated. Ternary complexes are formed by a simultaneous mechanism. The results showed the formation of Cu(HMI)L and Cu(HMI,H−1)(L) complexes. The stability of ternary complexes was quantitatively compared with their corresponding binary complexes in terms of the parameters Δlog 10 K and log 10 X. The effect of the side chains of amino acid ligands (ΔR) on complex formation was discussed. The concentration distributions of various species formed in solution were also evaluated as a function of pH. The thermodynamic parameters ΔH° and ΔS° calculated from the temperature dependence of the equilibrium constants are investigated. The effects of dioxane as a solvent, on the protonation constant of HMI and the formation constants of CuII–HMI complexes, were discussed.

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  1. Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt

    Ahmed A. El-Sherif

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El-Sherif, A.A. Mixed Ligand Complex Formation Reactions and Equilibrium Studies of Cu(II) with Bidentate Heterocyclic Alcohol (N,O) and Some Bio-Relevant Ligands. J Solution Chem 39, 131–150 (2010). https://doi.org/10.1007/s10953-009-9486-0

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