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Equilibrium and 1H NMR Kinetic Study of the Reactions of Dichlorido [S-Methyl-L-Cysteine(N,S)]Platinum(II) Complex with Some Relevant Biomolecules

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Abstract

The formation equilibria of the [Pt(SMC)(H2O)2]+ complex with some biologically relevant ligands such as L-methionine (L-met) and glutathione (GSH) were studied. The stoichiometry and stability constants of the formed complexes are reported, and the concentration distribution of the various complex species has been evaluated as a function of pH. The reaction between [PtCl2(SMC)] and guanosine-5′-monophosphate (5′-GMP) was studied by 1H NMR spectroscopy. The NMR spectra indicated that first step is the hydrolysis of the [PtCl2(SMC)] complex and second step is the substitution of an aqua ligand, either in the cis or trans position with guanosine-5′-monophosphate in molar ratio 1:1. The values of rate constant showed faster substitution of coordinated H2O in the trans position to the S donor atom of S-methyl-L-cysteine, whereas the slower reaction was assigned to the displacement of the cis coordinated aqua molecule. This is due to the strong trans labilization effect of coordinated sulfur.

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Authors and Affiliations

  1. Department of Technology, Chemistry and Biology, University of Novi Pazar, Vuka Karadžića bb, P. O. Box 67, 36300, Novi Pazar, Serbia

    Tanja Soldatović

  2. Faculty of Medicine, University of Kragujevac, S. Markovića 69, 34000, Kragujevac, Serbia

    Predrag Čanović & Radivoje Nikolić

  3. Faculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, P. O. Box 60, 34000, Kragujevac, Serbia

    Ratomir Jelić & Živadin D. Bugarčić

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  1. Tanja Soldatović
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  2. Predrag Čanović
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  3. Radivoje Nikolić
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  4. Ratomir Jelić
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  5. Živadin D. Bugarčić
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Correspondence to Živadin D. Bugarčić.

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Soldatović, T., Čanović, P., Nikolić, R. et al. Equilibrium and 1H NMR Kinetic Study of the Reactions of Dichlorido [S-Methyl-L-Cysteine(N,S)]Platinum(II) Complex with Some Relevant Biomolecules. J Solution Chem 38, 57–71 (2009). https://doi.org/10.1007/s10953-008-9346-3

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  • DOI: https://doi.org/10.1007/s10953-008-9346-3

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