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Polyacrylamide-coated MCM-48 mesoporous silica spheres: synthesis, characterization and drug delivery study

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Abstract

Mesoporous type-MCM-48 silica was grafted with polyacrylamide (PAAm) by using an azo-type initiator. The effect of monomer and initiator concentrations, reaction time, and temperature were evaluated to determine the optimal grafting conditions. Functionalized MCM-48 silicas were characterized by X-ray diffraction (XRD), infrared spectroscopy, thermogravimetric analysis, nitrogen adsorption–desorption analyses, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) which confirmed the grafting process. According to XRD, SEM and TEM results, PAAm-modified MCM-48 silica did not show changes in its morphology and mesostructure by comparing with pristine MCM-48. Also, modified silicas were tested as delivery system using nalidixic acid as drug model. MCM-48-PAAm silicas were able to load more significant amounts of nalidixic acid than the unmodified MCM-48, and showed a sustained delivery behaviour, releasing about 80% of drug.

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Acknowledgements

Authors thank the financial support of CIQA (project 6245). H.I. Melendez-Ortiz and L. García-Uriostegui are particularly grateful to the program Cátedras-CONACyT (Mexico). Also, we thank to E. Díaz, and H. Saade from CIQA for the TEM, and nitrogen adsorption–desorption studies respectively, and J.A. Mercado-Silva for his technical assistance.

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Authors and Affiliations

  1. CONACyT–Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo # 140, 25294, Saltillo, Coahuila, Mexico

    H. Iván Meléndez-Ortiz

  2. Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo # 140, 25294, Saltillo, Coahuila, Mexico

    Bertha Puente-Urbina

  3. Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Blvd. Venustiano Carranza, 25000, Saltillo, Coahuila, Mexico

    Erika Ibarra-Vallejo

  4. CONACyT - Departamento de Madera Celulosa y Papel, Universidad de Guadalajara, carretera Guadalajara-Nogales Km. 15.5, 45110, Zapopan, Jalisco, Mexico

    Lorena García-Uriostegui

  5. Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito exterior s/n, 04510, Mexico City, Mexico

    Alejandra Ortega

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  1. H. Iván Meléndez-Ortiz
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  2. Bertha Puente-Urbina
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Correspondence to H. Iván Meléndez-Ortiz.

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Meléndez-Ortiz, H.I., Puente-Urbina, B., Ibarra-Vallejo, E. et al. Polyacrylamide-coated MCM-48 mesoporous silica spheres: synthesis, characterization and drug delivery study. J Porous Mater 25, 649–656 (2018). https://doi.org/10.1007/s10934-017-0477-z

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  • DOI: https://doi.org/10.1007/s10934-017-0477-z

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