Abstract
In this study, chitosan (CS) encapsulated cobalt oxide nanoparticles modified with folic acid (FA) were synthesized and analyzed using different characterization techniques. A facile solvothermal method was performed to manufacture the CS-Cobalt oxide nanoparticles and FA-CS-Cobalt oxide nanoparticles. The obtained final products were subjected to X-ray diffraction spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy analyses. The UV–visible spectroscopy, Thermogravimetric and differential thermal analyses were employed to identify the optical and thermal properties of the synthesized nanoparticles. The net surface charge and the effective electric charge on the nanoparticles were determined by zeta potential analysis. The average crystallite size was calculated as 19.45 nm for chitosan-cobalt oxide nanoparticles and 16.36 nm for FA-CS-cobalt oxide nanoparticles.
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A.B. Vennela, D. Mangalaraj, N. Muthukumarasamy, S. Agilan, K.V. Hemalatha, Structural and optical properties of Co3O4 nanoparticles prepared by sol-gel technique for photocatalytic application. Int. J. Electrochem. Sci 14(4), 3535–3552 (2019)
Ahmed, H. M., & Mohamed, R. (2017). Optical And Electrical Properties Of Synthesized Cobalt Oxide (Co3O4) Nanoparticles Using Thermal Decomposition Method.
S. Chattopadhyay, S.K. Dash, T. Ghosh, D. Das, P. Pramanik, S. Roy, Surface modification of cobalt oxide nanoparticles using phosphonomethyl iminodiacetic acid followed by folic acid: a biocompatible vehicle for targeted anticancer drug delivery. Cancer Nanotechnol. 4(4), 103–116 (2013)
A. Rousta, D. Dorranian, M. Elahi, Electrophoretic deposition of cobalt oxide nanoparticles on aluminium substrate. Surf. Eng. 36(9), 919–928 (2020)
M. Radulescu, D. Ficai, O. Oprea, A. Ficai, E. Andronescu, M. Holban, Antimicrobial chitosan based formulations with impact on different biomedical applications. Curr. Pharm. Biotechnol. 16(2), 128–136 (2015)
A. Spoială, C.I. Ilie, G. Dolete, A.M. Croitoru, V.A. Surdu, R.D. Trușcă et al., Preparation and characterization of chitosan/TiO2 composite membranes as adsorbent materials for water purification. Membranes 12(8), 804 (2022)
S. Chattopadhyay, S.K. Dash, S. Kar Mahapatra, S. Tripathy, T. Ghosh, B. Das et al., Chitosan-modified cobalt oxide nanoparticles stimulate TNF-α-mediated apoptosis in human leukemic cells. J. Biol. Inorg. Chem. 19(3), 399–414 (2014)
G. Dolete, C. Chircov, L. Motelica, D. Ficai, O.C. Oprea, M. Gheorghe et al., Magneto-mechanically triggered thick films for drug delivery micropumps. Nanomaterials 12(20), 3598 (2022)
Z.C. Soe, B.K. Poudel, H.T. Nguyen, R.K. Thapa, W. Ou, M. Gautam et al., Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells. Asian J. Pharm. Sci. 14(1), 40–51 (2019)
D.B. Hazer Rosberg, B. Hazer, L. Stenberg, L.B. Dahlin, Gold and cobalt oxide nanoparticles modified poly-propylene poly-ethylene glycol membranes in poly (ε-Caprolactone) conduits enhance nerve regeneration in the sciatic nerve of healthy Rats. Int. J. Mol. Sci. 22(13), 7146 (2021)
A.S. El-Shafie, I. Ahsan, M. Radhwani, M.A. Al-Khangi, M. El-Azazy, Synthesis and application of cobalt oxide (Co3O4)-impregnated olive stones biochar for the removal of rifampicin and tigecycline: multivariate controlled performance. Nanomaterials 12(3), 379 (2022)
S. Law, A.W. Leung, C. Xu, Folic acid-modified celastrol nanoparticles: synthesis, characterization, anticancer activity in 2D and 3D breast cancer models. Artif. Cells Nanomed. Biotechnol. 48(1), 542–559 (2020)
R.W. Grimes, A.N. Fitch, Thermal decomposition of cobalt (II) acetate tetrahydrate studied with time-resolved neutron diffraction and thermogravimetric analysis. J. Mater. Chem. 1(3), 461–468 (1991)
L. Motelica, D. Ficai, A. Ficai, R.D. Truşcă, C.I. Ilie, O.C. Oprea, E. Andronescu, Innovative antimicrobial chitosan/ZnO/Ag NPs/citronella essential oil nanocomposites-Potential coating for grapes. Foods 9(12), 1801 (2020)
D. Gutiérrez-Martín, A. Varela, J.M. González-Calbet, E. Matesanz, M. Parras, Revisiting the decomposition process of tetrahydrate Co (II) acetate: a sample’s journey through temperature. Appl. Sci. 12(13), 6786 (2022)
S. Shahabuddin, N.M. Sarih, F.H. Ismail, M.M. Shahid, N.M. Huang, Synthesis of chitosan grafted-polyaniline/Co3O4 nanocube nanocomposites and their photocatalytic activity toward methylene blue dye degradation. RSC Adv. 5(102), 83857–83867 (2015)
Z. Song, Y. Zhang, W. Liu, S. Zhang, G. Liu, H. Chen, J. Qiu, Hydrothermal synthesis and electrochemical performance of Co3O4/reduced graphene oxide nanosheet composites for supercapacitors. Electrochim. Acta 112, 120–126 (2013)
L. Yu, Y. He, L. Bin, F. Yue’e, Study of radiation-induced graft copolymerization of butyl acrylate onto chitosan in acetic acid aqueous solution. J. Appl. Polym. Sci. 90(10), 2855–2860 (2003)
G.M. Al-Senani, N.M. Deraz, O.H. Abd-Elkader, Magnetic and characterization studies of CoO/Co3O4 nanocomposite. Processes 8(7), 844 (2020)
T. Athar, A. Hakeem, N. Topnani, A. Hashmi, Wet synthesis of monodisperse cobalt oxide nanoparticles. Int. Sch. Res. Notices (2012). https://doi.org/10.5402/2012/691032
J.S. Ajarem, S.N. Maodaa, A.A. Allam, M.M. Taher, M. Khalaf, Benign synthesis of cobalt oxide nanoparticles containing red algae extract: antioxidant, antimicrobial, anticancer, and anticoagulant activity. J. Clust. Sci. 33, 717–728 (2021)
N. Sharma, A.S. Reddy, K. Yun, Electrochemical detection of hydrocortisone using green-synthesized cobalt oxide nanoparticles with nafion-modified glassy carbon electrode. Chemosphere 282, 131029 (2021)
C.S. Jincy, P. Meena, Synthesis, characterization, and NH3 gas sensing application of Zn doped cobalt oxide nanoparticles. Inorg. Chem. Commun. 120, 108145 (2020)
Agnes. J, Ajith. P, Sappani Muthu. M, and D. Prem Anand. “ Synthesis and characterization studies of Mesostructured Chitosan coated CuO Nanoparticles with Folic acid. “ Journal of Xi’an Shiyou University, Natural sciences edition” 17: 274–285.
T. Xaba, L. Mokgoera, Z. Nate, P.M. Shumbula, Synthesis and characterization of cubic structured cobalt oxide nanoparticles capped with topo through the decomposition of bis (n-cyclohexyl-1-naphthaldehydato) cobalt (ii) complex as a single source precursor. Dig. J. Nanomater. Biostruct. 13(4), 1141–1147 (2018)
N. Iqbal, Tailoring g-C3N4 with lanthanum and cobalt oxides for enhanced photoelectrochemical and photocatalytic activity. Catalysts 12(1), 15 (2021)
D.F. Katowah, M.M. Rahman, M.A. Hussein, T.R. Sobahi, M.A. Gabal, M.M. Alam, A.M. Asiri, Ternary nanocomposite based poly (pyrrole-co-O-toluidine), cobalt ferrite and decorated chitosan as a selective Co2+ cationic sensor. Compos. B Eng. 175, 107175 (2019)
N. Akhlaghi, G. Najafpour-Darzi, H. Younesi, Facile and green synthesis of cobalt oxide nanoparticles using ethanolic extract of Trigonella foenumgraceum (Fenugreek) leaves. Adv. Powder Technol. 31(8), 3562–3569 (2020)
D.L. Liao, G.S. Wu, B.Q. Liao, Zeta potential of shape-controlled TiO2 nanoparticles with surfactants. Coll. Surfaces A: Physicochem. Eng. Aspects 348(1–3), 270–275 (2009)
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The authors thank St. Xavier’s College (Autonomous), Palayamkottai, and the Materials Research Centre for providing all the facilities and Dr. Lizie Williams, Assistant professor, Department of English for her constant support and encouragement.
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Agnes, J., Muthu, M.S., Ajith, P. et al. Preparation and Characterization of Chitosan-Encapsulated Cobalt Oxide Nanoparticles Modified with Folic Acid. J Inorg Organomet Polym 33, 555–561 (2023). https://doi.org/10.1007/s10904-022-02521-8
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DOI: https://doi.org/10.1007/s10904-022-02521-8