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Vitamin D Deficiency Among Newly Resettled Refugees in Massachusetts

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Abstract

Previous studies have indicated that vitamin D deficiency is widespread among immigrants and refugees. This study sought to determine the prevalence of vitamin D deficiency among a large and diverse cohort of refugees in Massachusetts to assess its significance for routine refugee health screening of refugees. 25-hydroxyvitamin D levels for 2,610 refugees screened between 2007 and 2009 were used to estimate vitamin D status and to examine the relationship between deficiency or insufficiency and age, gender, regional origin, and season of testing. Among those tested, 78 % were either vitamin D insufficient or deficient. Insufficiency or deficiency was most prevalent in refugees from the Middle East (89 %) and lowest in those from the Caribbean (59 %). Risk was higher among women than among men from some regions, such as the Middle East, but not others. For women, the likelihood of deficiency increased with age, while for men, the likelihood of deficiency was similar for preschool children and men at the height of their working years. The high overall prevalence of vitamin D deficiency suggests that empiric supplementation or treatment may be preferred to testing until more is known about the long-term epidemiology of vitamin D deficiency and its consequences.

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References

  1. Karfunkel P. Vitamin D levels in men in a single primary care practice near Boston. Am J Mens Health. 2007;1:262–8.

    Article  PubMed  Google Scholar 

  2. Madar AA, Stene LC, Meyer HE. Vitamin D status among immigrant mothers from Pakistan, Turkey and Somalia and their infants attending child health clinics in Norway. Br J Nutr. 2009;101:1052–8.

    Article  PubMed  CAS  Google Scholar 

  3. Andersen R, Mølgaard C, Skovgaard LT, et al. Pakistani immigrant children and adults in Denmark have severely low vitamin D status. Eur J Clin Nutr. 2008;62:625–34.

    Article  PubMed  CAS  Google Scholar 

  4. McGillivray G, Skull SA, Davie G, et al. High prevalence of asymptomatic vitamin D and iron deficiency in East African immigrant children and adolescents living in a temperate climate. Arch Dis Child. 2007;92:1088–93.

    Article  PubMed  Google Scholar 

  5. Glerup H, Rytter L, Mortensen L, Nathan E. Vitamin D deficiency among immigrant children in Denmark. Eur J Pediatr. 2004;163:272–3.

    Article  PubMed  Google Scholar 

  6. Brock K, Wilkinson M, Cook R, Lee S, Bermingham M. Associations with Vitamin D deficiency in “at risk” Australians. J Steroid Biochem Mol Biol. 2004;89–90:581–8.

    Article  PubMed  Google Scholar 

  7. Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary reference intakes for calcium and vitamin D. Washington, DC: Institute of Medicine; 2011.

    Google Scholar 

  8. Alver K, Meyer HE, Falch JA, Søgaard AJ. Bone mineral density in ethnic Norwegians and Pakistani immigrants living in Oslo—the Oslo Health Study. Osteoporos Int. 2005;16:623–30.

    Article  PubMed  Google Scholar 

  9. Holvik K, Meyer HE, Haug E, Brunvand L. Prevalence and predictors of vitamin D deficiency in five immigrant groups living in Oslo, Norway: the Oslo Immigrant Health Study. Eur J Clin Nutr. 2005;59:57–63.

    Article  PubMed  CAS  Google Scholar 

  10. van der Meer IM, Karamali NS, Boeke AJ, et al. High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague Netherlands. Am J Clin Nutr. 2006;84:350–3.

    PubMed  Google Scholar 

  11. Hintzpeter B, Scheidt-Nave C, Müller MJ, Schenk L, Mensink GB. Higher prevalence of vitamin D deficiency is associated with immigrant background among children and adolescents in Germany. J Nutr. 2008;138:1482–90.

    PubMed  CAS  Google Scholar 

  12. Wishart HD, Reeve AM, Grant CC. Vitamin D deficiency in a multinational refugee population. Intern Med J. 2007;37:792–7.

    Article  PubMed  CAS  Google Scholar 

  13. Sheikh M, Wang S, Pal A, MacIntyre CR, Wood N, Gunesekera H. Vitamin D deficiency in refugee children from conflict zones. J Immigr Minor Health. 2011;13:87–93.

    Article  PubMed  Google Scholar 

  14. Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78:1463–70.

    Article  PubMed  Google Scholar 

  15. Huntington MK, Shafer CW, Pudwill R, Boer L, Kendall J. Prevalence of vitamin D deficiency among immigrants to South Dakota. S D Med. 2010;63:51–5.

    PubMed  Google Scholar 

  16. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. JCEM. 2011;96:1911–30.

    PubMed  CAS  Google Scholar 

  17. Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med. 2004;158:531–7.

    Article  PubMed  Google Scholar 

  18. Merewood A, Mehta SD, Grossman X, Chen TC, Mathieu JS, Holick MF, Bauchner H. Widespread vitamin D deficiency in urban Massachusetts newborns and their mothers. Pediatrics. 2010;125:640–7.

    Article  PubMed  Google Scholar 

  19. Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol. 2007;103:620–5.

    Article  PubMed  CAS  Google Scholar 

  20. Hobbs Rd, Habib Z, Alromaihi D, et al. Severe vitamin D deficiency in Arab-American women living in Dearborn, Michigan. Endocr Pract. 2009;15:35–40.

    PubMed  Google Scholar 

  21. Reed SD, Laya MB, Melville J, Ismali SY, Mitchell CM, Ackerman DR. Prevalence of vitamin D insufficiency and clinical associations among veiled East African women in Washington State. J Women’s Health. 2007;16:206–13.

    Article  Google Scholar 

  22. Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int. 2006;17:1133–40.

    Article  PubMed  CAS  Google Scholar 

  23. Benson J, Skull S. Hiding from the sun—vitamin D deficiency in refugees. Aust Fam Physician. 2007;36:355–7.

    PubMed  Google Scholar 

  24. Peterlik M, Boonen S, Cross HS, Lamberg-Allardt C. Vitamin D and calcium insufficiency-related chronic diseases as an emerging world-wide public health problem. Int J Environ Res Public Health. 2009;6:2585–607.

    Article  PubMed  CAS  Google Scholar 

  25. van der Meer IM, Middelkoop BJ, Boeke AJ, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian, and sub-Sahara African populations in Europe and their countries of origin: an overview. Osteoporos Int. 2011;22:1009–21.

    Article  PubMed  CAS  Google Scholar 

  26. de Torrenté de la Jara G, Pécoud A, Favrat B. Musculoskeletal pain in female asylum seekers and hypovitaminosis D3. BMJ. 2004;329:156–7.

    Article  PubMed  Google Scholar 

  27. Dealberto MJ. Why are immigrants at increased risk for psychosis? Vitamin D insufficiency, epigenetic mechanisms, or both? Med Hypotheses. 2007;68:259–67.

    Article  PubMed  CAS  Google Scholar 

  28. Powe CE, Seely EW, Rana S, et al. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension. 2010;56:758–63.

    Article  PubMed  CAS  Google Scholar 

  29. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol. 2010;203:366.

    Article  PubMed  Google Scholar 

  30. Thandrayen K, Pettifor JM. Maternal vitamin D status: implications for the development of infantile nutritional rickets. Endocrinol Metab Clin North Am. 2010;39:303–20.

    Article  PubMed  CAS  Google Scholar 

  31. Wang J, Yang F, Mao M, Liu DH, Yang HM, Yang SF. High prevalence of vitamin D and calcium deficiency among pregnant women and their newborns in Chengdu, China. World J Pediatr. 2010;6:265–7.

    Article  PubMed  Google Scholar 

  32. Rook GAW. The role of vitamin D in tuberculosis. Am Rev Respir Dis. 1988;138:768–70.

    Article  PubMed  CAS  Google Scholar 

  33. Chan TYK. Vitamin D deficiency and susceptibility to tuberculosis. Calcif Tissue Int. 2000;6:476–8.

    Article  Google Scholar 

  34. Ustianowski A, Shaffer R, Collin S, Wilkinson RJ, Davidson RN. Prevalence and associations of vitamin D deficiency in foreign-born persons with tuberculosis in London. J Infect. 2005;50:432–7.

    Article  PubMed  CAS  Google Scholar 

  35. Talat N, Perry S, Parsonnet J, Dawood G, Hussain R. Vitamin D deficiency and tuberculosis progression. Emerg Infect Dis. 2010;16:853–5.

    Article  PubMed  CAS  Google Scholar 

  36. Gibney KB, MacGregor L, Leder K, et al. Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clin Infect Dis. 2008;46:443–6.

    Article  PubMed  CAS  Google Scholar 

  37. Centers for Disease Control and Prevention. Decrease in reported tuberculosis cases—United States, 2009. MMWR. 2010;59:289–94.

    Google Scholar 

  38. Holick MF. Vitamin D deficiency. NEJM. 2007;357:266–81.

    Article  PubMed  CAS  Google Scholar 

  39. Benitez-Aguirre PZ, Wood MJ, Biesheuvel C, Moreira C, Munns CF. The natural history of vitamin D deficiency in African refugees living in Sydney. Med J Aust. 2009;190:426–8.

    PubMed  Google Scholar 

  40. Binet A, Kooh SW. Persistence of vitamin D-deficient rickets in Toronto in the 1990 s. Can J Public Health. 1996;87:227–30.

    PubMed  CAS  Google Scholar 

  41. Meyer HE, Holvik K, Lofthus CM, Tennakoon SU. Vitamin D status in Sri Lankans living in Sri Lanka and Norway. Br J Nutr. 2008;99:941–4.

    Article  PubMed  CAS  Google Scholar 

  42. Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med. 2002;112:659–62.

    Article  PubMed  CAS  Google Scholar 

  43. Skull SA, Ngeow JY, Biggs BA, Street A, Ebeling PR. Vitamin D deficiency is common and unrecognized among recently arrived adult immigrants from the Horn of Africa. Intern Med J. 2003;33:47–51.

    Article  PubMed  CAS  Google Scholar 

  44. Stellinga-Boelen AA, Wiegersma PA, Storm H, Bijleveld CM, Verkade HJ. Vitamin D levels in children of asylum seekers in The Netherlands in relation to season and dietary intake. Eur J Pediatr. 2007;166:201–6.

    Article  PubMed  CAS  Google Scholar 

  45. Andersen R, Mølgaard C, Skovgaard LT, et al. Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomized double-blinded placebo-controlled intervention study. Br J Nutr. 2008;100:197–207.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Katherine Penrose.

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Penrose, K., Hunter Adams, J., Nguyen, T. et al. Vitamin D Deficiency Among Newly Resettled Refugees in Massachusetts. J Immigrant Minority Health 14, 941–948 (2012). https://doi.org/10.1007/s10903-012-9603-9

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