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Syntheses, Structural, and Biological Studies of Two New Peptide Compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl Acetate Hemihydrate and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl Acetic Acid

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Abstract

Two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate (1:1/2H 2 O) and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid (2), have been synthesized and characterized by elemental analysis, IR, 1H- and 13C NMR spectroscopy. Two new compounds were structurally characterized by single-crystal X-ray diffraction. The thermal stabilities of compounds 1:1/2H 2 O and 2 were studied by DSC-TGA techniques. The result of the biological test showed that the compounds 1:1/2H 2 O and 2 have certain antitumor activities.

Index Abstract

Two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate (1:1/2H2O) and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid (2), have been synthesized and characterized by elemental analysis, IR, 1H-, and 13C NMR spectroscopy. Two new compounds were structurally characterized by single-crystal X-ray diffraction. The thermal stabilities of compounds 1:1/2H2O and 2 were studied by DSC-TGA techniques. The result of the biological test showed that the compounds 1:1/2H2O and 2 have certain antitumor activities.

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Acknowledgment

We acknowledge financial support by the National Natural Science Foundation of China (No. 20571057).

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Authors and Affiliations

  1. College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, 325027, People’s Republic of China

    Mao-Lin Hu, Ping Yin & Zhi-Cheng Ma

  2. Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, 14115-175, Islamic Republic of Iran

    Ali Morsali

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  1. Mao-Lin Hu
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  2. Ping Yin
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  3. Zhi-Cheng Ma
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  4. Ali Morsali
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Correspondence to Mao-Lin Hu.

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Hu, ML., Yin, P., Ma, ZC. et al. Syntheses, Structural, and Biological Studies of Two New Peptide Compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl Acetate Hemihydrate and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl Acetic Acid. J Chem Crystallogr 38, 807–813 (2008). https://doi.org/10.1007/s10870-008-9396-9

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  • DOI: https://doi.org/10.1007/s10870-008-9396-9

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