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Preparation of sulfonated porous carbon nanotubes/activated carbon composite beads and their adsorption of low density lipoprotein

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Abstract

The high level of low density lipoprotein (LDL) in plasma is the main cause of atherosclerosis. Hemoperfusion is an ideal therapy to lower the level of LDL in human blood system while therapeutic effect is determined by the adsorbent. The adsorbent must have suitable pore structure and specific functional groups. Carbon nanotubes (CNTs) could be a new adsorbent material because CNTs have high specific surface area and they can be modified by a variety of functional groups. Porous carbon composite beads with the CNTs and phenolic resin mixture were synthesized by suspension polymerization, following with carbonization and steam-activation. Then the porous composite beads were sulfonated with a sulfanilic acid anhydrous by diazotization and coupling reaction. The potential application of the sulfonated porous composite beads in adsorbing low density lipoprotein (LDL) from human serum was investigated. The results showed that the sulfonic acid groups on the composite beads could lower LDL levels greatly by electrostatic interaction with electropositive LDL. The higher 20–100 nm pore volume the composite beads had, the more LDL they could adsorb. The 20–100 nm pore volume was enhanced by adding more CNTs and improving CNTs dispersion (ultrasonic crushing). The sulfonated composite beads containing 45 wt% CNTs presented the highest adsorption capacity to LDL 10.46 mg/g, showing a good prospect as LDL adsorbent in hemoperfusion.

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Acknowledgments

This research was supported by the Natural Science Foundation of China (No. 50602026).

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Authors and Affiliations

  1. Department of Mechanical Engineering, Tsinghua University, 100084, Beijing, People’s Republic of China

    Yuemei Lu, Qianming Gong & Ji Liang

  2. Key Laboratory for Advanced Materials Processing Technology, Ministry of Education, 100084, Beijing, People’s Republic of China

    Yuemei Lu, Qianming Gong & Ji Liang

  3. Department of Materials Science and Engineering, Cornell University, Ithaca, 14850, USA

    Qianming Gong

  4. Department of Nephrology, The First Affiliated Hospital of Tsinghua University, 100016, Beijing, People’s Republic of China

    Fangping Lu

  5. Department of Materials, Imperial College London, London, SW7 2AZ, UK

    Lijun Ji

  6. Tsinghua University Hospital, 100084, Beijing, People’s Republic of China

    Qingdong Nie & Xiumei Zhang

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  1. Yuemei Lu
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Correspondence to Yuemei Lu.

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Lu, Y., Gong, Q., Lu, F. et al. Preparation of sulfonated porous carbon nanotubes/activated carbon composite beads and their adsorption of low density lipoprotein. J Mater Sci: Mater Med 22, 1855–1862 (2011). https://doi.org/10.1007/s10856-011-4368-6

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  • DOI: https://doi.org/10.1007/s10856-011-4368-6

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