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Biological properties of carbon/carbon implant composites with unique manufacturing processes

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Abstract

The goal was to manufacture carbon/carbon (C/C) composites through a unique procedure with improved biocompatibility and reduced debris release. C/C composites were prepared by chemical vapor deposition, and their biological properties were analyzed. With regard to mechanical properties, compressive strength/modulus was 219.1 MPa/9.72 GPa, flexural strength/modulus was 121.63 MPa/21.9 GPa, and interlaminar sheer was 15.13 GPa. Biocompatibility testing revealed: (1) the extract liquid from the C/C composites had no effect on cell proliferation; (2) the extract had no impact on micronucleus frequency as compared with the control groups (P > 0.05); (3) in vivo, there was mild tissue inflammation after implantation within the first 2 weeks, but there was no significant difference compared with the control group (P > 0.05); (4) the implants were well integrated into the host tissue, and debris was limited. The tested samples have excellent biocompatibilities and reduced release of debris. The demonstrated changes in manufacturing procedures are promising.

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Acknowledgment

We would like to thank Shuolun Ruan for providing valuable feedback and proofreading the manuscript.

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Authors and Affiliations

  1. Transplantation Medical Academy, Third XiangYa Hospital, Central South University, Changsha, 410013, People’s Republic of China

    Guo-Hui Wang, Shai-Hong Zhu, Chang-Qing Gao & Yong Liu

  2. State Key Laboratory for Power Metallurgy, Central South University, Changsha, 410083, People’s Republic of China

    Shu Yu & Bo-Yun Huang

  3. Tianniao High-tech Limited Company, Yixing, 214216, People’s Republic of China

    Yun-Liang Miu

Authors
  1. Guo-Hui Wang
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  2. Shu Yu
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  3. Shai-Hong Zhu
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  4. Chang-Qing Gao
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  5. Yong Liu
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  6. Yun-Liang Miu
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Corresponding author

Correspondence to Shai-Hong Zhu.

Additional information

Guo-Hui Wang and Shu Yu these two authors contributed equally to this work.

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Wang, GH., Yu, S., Zhu, SH. et al. Biological properties of carbon/carbon implant composites with unique manufacturing processes. J Mater Sci: Mater Med 20, 2487–2492 (2009). https://doi.org/10.1007/s10856-009-3812-3

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  • DOI: https://doi.org/10.1007/s10856-009-3812-3

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