Abstract
The potential differences in bone repair of calvaria defects treated with a collagen sponge (HELISTAT®) or a collagen-hydroxyapatite composite (HEALOS®) in young and aged rats were evaluated at 8 weeks after surgery. A histomorphometric analysis of new bone formation and an evaluation of angiogenesis, mast cell, and eosinophil local infiltration were performed. Evaluation showed that HELISTAT® induced a similar amount of new bone in both young and aged rats. However this occurred to a lesser degree than in young rats treated with HEALOS®. The largest number of blood vessels was present in the defects of aged rats treated with HEALOS®, and the number of mast cells was highest in the defects treated with HELISTAT® in both young and aged rats. Eosinophils were present to the greatest extent in defects treated with HEALOS® in comparison to defects treated with HELISTAT® in both young and aged rats. Collagen-hydroxyapatite composite (HEALOS®) enhances calvarial bone repair more than collagen sponge alone (HELISTAT®) in young rats but not in aged rats at 8 weeks after surgery. HEALOS® appears to induce a more intense inflammatory response than HELISTAT® especially in aged rats.
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We would like to thank Rachael Sugars for critical review of the manuscript. This work was supported by funds from the Swedish Research Council, Stockholm City Council, and Karolinska Institutet.
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Tcacencu, I., Wendel, M. Collagen-hydroxyapatite composite enhances regeneration of calvaria bone defects in young rats but postpones the regeneration of calvaria bone in aged rats. J Mater Sci: Mater Med 19, 2015–2021 (2008). https://doi.org/10.1007/s10856-007-3284-2
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DOI: https://doi.org/10.1007/s10856-007-3284-2