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Preparation of cerium oxide–MWCNTs nanocomposite bulk modified carbon ceramic electrode: a sensitive sensor for tamoxifen determination in human serum samples

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Abstract

In this study, cerium oxide and multi-walled carbon nanotubes nanocomposite were incorporated into the carbon ceramic electrode (CeO2–MWCNTs/CCE) as a renewable electrode for the electrocatalytic purposes. To demonstrate capability of the fabricated electrode, determination of tamoxifen as an important anticancer drug with differential pulse voltammetry technique was evaluated in details. Linear range, limit of detection and sensitivity of the developed sensor were found to be 0.2–40 nM, 0.132 nM and 1.478 µA nM−1 cm−2, respectively. Ease of production, low cost and high electron transfer rate of the CeO2–MWCNTs/CCE promises it as a novel electro-analytical tool for determination of important species in real samples.

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Data availability

The data that support the findings of this study are available from the corresponding authors upon reasonable request.

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Acknowledgements

The authors gratefully acknowledge the Sirjan School of Medical Sciences and Research Council of Azarbaijan Shahid Madani University for financial support.

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Authors and Affiliations

  1. Electrochemistry Research Lab., Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran

    Sepideh Shafaei & Rahim Mohammad-Rezaei

  2. Department of Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, Iran

    Elyas Hosseinzadeh

  3. Department of Chemistry, Faculty of Science, Yuzuncu Yil University, 65080, Van, Turkey

    Gulsah Saydan Kanberoglu

  4. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Balal Khalilzadeh

  5. Biosensor Sciences and Technologies Research Center (BSTRC), Ardabil University of Medical Sciences, Ardabil, Iran

    Balal Khalilzadeh

Authors
  1. Sepideh Shafaei
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  2. Elyas Hosseinzadeh
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  3. Gulsah Saydan Kanberoglu
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  4. Balal Khalilzadeh
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  5. Rahim Mohammad-Rezaei
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Corresponding authors

Correspondence to Elyas Hosseinzadeh or Rahim Mohammad-Rezaei.

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The authors have no conflicts of interest to declare. All co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report. We certify that the submission is original work and is not under review at any other publication.

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Supplementary Information

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Supplementary file1 (DOCX 63 kb) XRD pattern of CeO2–MWCNT/CCE

10854_2021_6019_MOESM2_ESM.docx

Supplementary file2 (DOCX 160 kb) A CVs of bare-CCE in 0.01 M [Fe(CN)6]3− at 0.1 M acetate buffer solution in different scan rates of 10, 25, 50, 75, 100, 150, 200, 250, 300, 400 and 500 mV s−1, and B change of peak currents vs. square root of scan rate

10854_2021_6019_MOESM3_ESM.docx

Supplementary file3 (DOCX 142 kb) A CVs of CeO2–MWCNT/CCE in 0.01 M [Fe(CN)6]3− at 0.1 M acetate buffer solution in different scan rates of 10, 25, 50, 75, 100, 150, 200, 250, 300, 400 and 500 mV s−1, and B change of peak currents vs. square root of scan rate

10854_2021_6019_MOESM4_ESM.docx

Supplementary file4 (DOCX 67 kb) A CVs of CeO2–MWCNT/CCE in the presence of TAM with different concentrations of 4.5, 5, 5.5, 6, 6.5, 7, 7.5 and 8 µM. B The corresponding calibration curve

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Shafaei, S., Hosseinzadeh, E., Kanberoglu, G.S. et al. Preparation of cerium oxide–MWCNTs nanocomposite bulk modified carbon ceramic electrode: a sensitive sensor for tamoxifen determination in human serum samples. J Mater Sci: Mater Electron 32, 14601–14609 (2021). https://doi.org/10.1007/s10854-021-06019-w

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  • DOI: https://doi.org/10.1007/s10854-021-06019-w

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