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Optimized-dose lidocaine-loaded sulfobutyl ether β-cyclodextrin/hyaluronic acid hydrogels to improve physical, chemical, and pharmacological evaluation for local anesthetics and drug delivery systems

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Abstract

Local anesthetics (LAs) are a class of drugs, which have wide applications in the treatment of post-operative pain care management. Long-acting LAs that can be given as a single dose analgesic are desperately needed. The prepared sulfobutylether β-cyclodextrin (SCD)/hyaluronic acid (HA) hydrogels were characterized by Fourier transform infrared and X-ray diffraction patterns. The as-prepared SCD/HA hydrogels greatly enhanced their swelling behavior and in vitro degradation properties. Furthermore, a scanning electron microscope reported that the surface morphology of the Lidocaine (LDC)-loaded SCD/HA hydrogels was smooth, and a significant change in porosity was observed after the addition of LDC (0.5%, 1.0%, and 1.5% w/v). The occurrence of cross-linking between the LDC and SCD/HA hydrogels was studied through rheological analysis. Approximately 94% of lidocaine (LDC) was released from the SCD/HA-LDC formulations by 24 h. The cytotoxicity of SCD/HA-LDC was studied against fibroblast (3T3) cells. SCD/HA-LDC showed a prolonged in vitro release and lower cytotoxicity when compared to free LDC. Furthermore, in vivo evaluation of the anesthetic properties in animal models showed that the SCD/HA-LDC showed a significantly prolonged analgesic effect when compared to free LDC. Moreover, the SCD/HA-LDC exhibited good biodegradability and biocompatibility in histological analyses. Overall, the findings suggest that the LDC-loaded SCD/HA hydrogels had a synergistic impact in prolonging analgesia without generating toxicity, and hence might be used as a long-acting analgesia therapeutic care.

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Acknowledgements

The authors are grateful to all the testing technicians for their technical supports.

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Authors and Affiliations

  1. Department of Endocrinology, First Hospital of Lanzhou University, Lanzhou, China

    Li-Yuan Zhou

  2. School of Nursing Care, Lanzhou University, Lanzhou, China

    Yan-Hong Wang

  3. Department of Geriatric, First Hospital of Lanzhou University, Lanzhou, China

    Rong-Rong Pan

  4. Department of Anesthesiology and Operation, First Hospital of Lanzhou University, No. 1 West Donggang Road, Chengguan District, Lanzhou, 730000, China

    Zhan-Hai Wan, Meng-Jie Zhang & Ya-Tao Liu

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Zhou, LY., Wang, YH., Pan, RR. et al. Optimized-dose lidocaine-loaded sulfobutyl ether β-cyclodextrin/hyaluronic acid hydrogels to improve physical, chemical, and pharmacological evaluation for local anesthetics and drug delivery systems. J Mater Sci 57, 7068–7084 (2022). https://doi.org/10.1007/s10853-022-07072-4

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