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Evaluation of poly (L-lactic acid) monofilaments with high mechanical performance in vitro degradation

  • Materials for life sciences
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Abstract

Nowadays, the degradation properties of poly (L-lactic acid) (PLLA) braided stents are still not well understood. The main challenge relies on the unknown degradation behavior of the PLLA monofilaments, which is the fundamental element of the braided stent. In this paper, the solid-state drawn PLLA monofilament in vitro degradation has been studied. A one-year experiment data was conducted to evaluate degradation properties, including the mass loss, morphology, characterization, and mechanical properties. Within the first 3 months, changes in the mass loss, crystallinity, and mechanical performance of the monofilament were very gentle. The monofilament molecular weight was significantly reduced after each degradation stage and decreased by more than 90% at the end of the one-year degradation. Moreover, the mechanical properties of the annealed monofilament were retained better than that of the unannealed monofilament after 6 months. Therefore, this study may provide preliminary experimental references for evaluating the degradation performance of PLLA braided stents.

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Acknowledgements

This work was financially supported by the National Key Research and Development Programme of China (No. 2018YFA0704102), the National Natural Science Foundation of China (Grant Nos. 51775107 and 51905276).

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Authors and Affiliations

  1. School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, 211189, China

    Gutian Zhao, Bin Wang, Xin Li, Muqing Liu, Yuan Tian, Jing Zhang, Jie Cheng, Juekuan Yang & Zhonghua Ni

  2. Department of Radiology, Center of Interventional Radiology & Vascular Surgery, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210044, China

    Yi Zhang

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  1. Gutian Zhao
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  2. Bin Wang
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  3. Xin Li
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Correspondence to Juekuan Yang or Zhonghua Ni.

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Zhao, G., Wang, B., Li, X. et al. Evaluation of poly (L-lactic acid) monofilaments with high mechanical performance in vitro degradation. J Mater Sci 57, 6361–6371 (2022). https://doi.org/10.1007/s10853-022-07049-3

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  • DOI: https://doi.org/10.1007/s10853-022-07049-3

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