Abstract
The risk assessment of SiO2 nanoparticles has attracted extensive attention due to their great potential for various commercial purposes. However, the toxicity of mesoporous SiO2-based nanocomposite is still unclear. Herein SiO2-based hexagonal mesoporous nanosphere doping La3+ ions with diameter of 40–50 nm (SLa-HMS) and micronsized SiO2-based hexagonal mesoporous solid inlaid with nanowires, 80–250 nm in length and 4–5 nm in diameter, of La species (WLa-HMS) were synthesized via self-assembly method. The specimens were characterized by small angle XRD, TEM, EDS, FT-IR, and N2 ad–desorption. HeLa, fibroblast, and HBMSC cells were exposed to 0.1–100 μg/mL of SLa-HMS and WLa-HMS colloids for 12, 24, 48, and 72 h. Our data demonstrated that exposure of SLa-HMS in the dose range tested had no hazardous effect on all three cell lines, which was greatly different from previous reports. However, the WLa-HMS with average particle size of 10–19 μm was proven to be very toxic to the growth of all three cell lines. These interesting findings strongly suggest that doping heteroatom could be a way to improve the cytotoxicity of nanomaterials, as well as to oncotherapy on the basis of the hazardous effect of nanomaterials.
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Acknowledgements
This study was financially supported by high technology study plan of China (Grant No. 2007AA021908), Key Project of Chinese National Programs for Fundamental Research and Development (A00102110400). Chinese National Natural Science Foundation grants 30772178 (to X.G.), 30973011 (to X.G.), and 30901496 (to J.P.), the Key Project of Guangdong Provincial Science and Technology Research grant 7117362 (to X.G.) and the Chinese National High-Tech Research and Development Program grant 2007AA021906 (to X.G.).
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Wusheng Guo and Yun Luo contributed equally to this study.
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Guo, W., Luo, Y., Wei, K. et al. A cellular level biocompatibility and biosafety evaluation of mesoporous SiO2-based nanocomposite with lanthanum species. J Mater Sci 47, 1514–1521 (2012). https://doi.org/10.1007/s10853-011-5938-1
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DOI: https://doi.org/10.1007/s10853-011-5938-1