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Binding behaviors of scutellarin with α-, β-, γ-cyclodextrins and their derivatives

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Abstract

A series of cyclodextrin/scutellarin inclusion complexes were prepared from α-cyclodextrin, β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin with scutellarin (SCU), and their inclusion complexation behaviors, such as stoichiometry, complex stability constants and inclusion mode, were investigated by means of UV/Vis spectroscopy, 1H NMR and 2D NMR. The results showed that the SCU could be efficiently encapsulated in the cyclodextrin cavity in aqueous solution to produce complexes that were more soluble than free SCU. The enhanced binding ability of cyclodextrins towards SCU was discussed from the viewpoint of the size/shape-fit and multiple recognition mechanism between host and guest.

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Acknowledgments

This work was supported by the Opening Foundation of State Key Laboratory of Elemento-Organic Chemistry of Nankai University (0607 and 0704), which is gratefully acknowledged.

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Authors and Affiliations

  1. School of Chemistry, Key Laboratory of Medicinal Chemistry for Natural Resource (Ministry of Education), Yunnan University, 650091, Kunming, People’s Republic of China

    Bo Yang, Li-Juan Yang & Jun Lin

  2. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 300071, Tianjin, People’s Republic of China

    Bo Yang, Yong Chen & Yu Liu

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  1. Bo Yang
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  2. Li-Juan Yang
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  3. Jun Lin
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  4. Yong Chen
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  5. Yu Liu
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Correspondence to Jun Lin or Yu Liu.

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Yang, B., Yang, LJ., Lin, J. et al. Binding behaviors of scutellarin with α-, β-, γ-cyclodextrins and their derivatives. J Incl Phenom Macrocycl Chem 64, 149–155 (2009). https://doi.org/10.1007/s10847-009-9547-4

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  • DOI: https://doi.org/10.1007/s10847-009-9547-4

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