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Effect of β-cyclodextrin on the aggregation of the non-ionic surfactant Igepal CO-630 in water as studied by 1D and 2D NMR spectroscopy

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Abstract

The micellization process of the non-ionic surfactant, Igepal CO-630, and its inclusion complexes with β-cyclodextrin (β-CD) have been investigated by NMR spectroscopy. The critical micelle concentration of Igepal was determined by measuring the chemical shifts of different resonances. The structure and binding of the inclusion complexes between the Igepal and the β-CD have been studied by 1D proton NMR and ROESY experiments. The stoichiometry of the inclusion complex is mainly 1:1, with a slight contribution of 2:1. At high concentrations of surfactant, the plots of the chemical shifts in the absence and presence of β-CD coalesce, which indicates that the complexes do not take part into the micelles. The ROESY spectrum displays strong correlations between the internal cavity protons of the CD and the aromatic and aliphatic regions of the Igepal, suggesting the formation of a 2:1 primary face-to-face inclusion complex at high concentrations of β-CD.

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Acknowledgements

The authors acknowledge financial support from the UCM (PR1/06-14507) and Ministerio de Ciencia y Tecnología (CTQ2006-14933), and the “Centro de Resonancia Magnética Nuclear” of the Univerisdad Complutense.

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Correspondence to A. Guerrero-Martínez.

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Guerrero-Martínez, A., González-Gaitano, G., Murciano, E.M. et al. Effect of β-cyclodextrin on the aggregation of the non-ionic surfactant Igepal CO-630 in water as studied by 1D and 2D NMR spectroscopy. J Incl Phenom Macrocycl Chem 57, 251–256 (2007). https://doi.org/10.1007/s10847-006-9188-9

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  • DOI: https://doi.org/10.1007/s10847-006-9188-9

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