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Obstetrical and neonatal outcomes after vitrified-warmed blastocyst transfer in day 1 rescue intracytoplasmic sperm injection cycles: a retrospective cohort study

  • Assisted Reproduction Technologies
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Abstract

Background

Fertilization failure often occurs in conventional IVF cycles, and day 1 rescue ICSI is frequently recommended. In this study, the effect of rescue ICSI on obstetrical and neonatal outcomes after a single blastocyst transfer in vitrified-warmed cycles is evaluated.

Methods

This cohort study was a retrospective analysis of 703 vitrified-warmed single blastocyst transfers and 219 singletons in the r-ICSI group compared with 11,611 vitrified-warmed single blastocyst transfers in the IVF/ICSI and 4472 singletons in the IVF/ICSI group, respectively, and patients just undergoing their first IVF treatments were included in this study. Pregnancy rate (PR), live birth rate (LBR), and singleton birthweight were the primary outcome measures. Multiple linear regression analysis and logistic regression analysis were performed to evaluate the possible relationship between obstetrical and neonatal outcomes and fertilization method (including IVF, ICSI, and r-ICSI) after adjusting for other potential confounding factors.

Results

PR and the LBR were lower in the r-ICSI group compared with the IVF/ ICSI group. Singletons from the r-ICSI group had a higher Z-score and the proportion of large for gestational age (LGA) newborns was greater compared with singletons from the IVF/ICSI group.

Conclusion

The results of the study indicated that a 31% LBR after r-ICSI is acceptable for vitrified-warmed blastocyst transfer, but the safety of transfer is a concern because of the lower PR and LBR compared with IVF/ICSI. The safety of r-ICSI newborns is also a concern because of the significantly higher birthweight and the proportion of LGA in r-ICSI group newborns compared with the IVF/ICSI group.

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Data availability

Data generated or analyzed are included in this article. Further inquiries can be directed to the corresponding author.

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Funding

This study was supported by the National Key R&D Program of China (no. 2023YFC2705604) and the National Science Foundation of China (82071721, 82371706 and 82288102).

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Center for Reproductive Medical, Peking University Third Hospital, Haidian District, No. 49 North Huayuan Road, Beijing, 10091, China

    Ming Li, Nan Zhang, Jin Huang, Qin Li, JunSheng Li, Rong Li, Ping Liu & Jie Qiao

  2. Key Laboratory of Assisted Reproduction Peking University, Ministry of Education, Beijing, 10091, China

    Ming Li, Nan Zhang, Jin Huang, Qin Li, JunSheng Li, Rong Li, Ping Liu & Jie Qiao

  3. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction Technology, Beijing, 100191, China

    Ming Li, Nan Zhang, Jin Huang, Qin Li, JunSheng Li, Rong Li, Ping Liu & Jie Qiao

  4. National Clinical Research Center for Obstetrics and Gynecology, Beijing, 10091, China

    Ming Li, Nan Zhang, Jin Huang, JunSheng Li, Rong Li, Ping Liu & Jie Qiao

  5. Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 10091, China

    Qin Li

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  1. Ming Li
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Correspondence to Ming Li or Ping Liu.

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The study was approved by the Ethics Committee of Beijing University Third Hospital (reference no: 2022SZ-070), and all patients signed written informed consent.

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Li, M., Zhang, N., Huang, J. et al. Obstetrical and neonatal outcomes after vitrified-warmed blastocyst transfer in day 1 rescue intracytoplasmic sperm injection cycles: a retrospective cohort study. J Assist Reprod Genet (2024). https://doi.org/10.1007/s10815-024-03126-5

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