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Potential roles of experimental reproductive technologies in infertile women with diminished ovarian reserve

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Abstract

In assisted reproductive technology treatment, diminished ovarian reserve (DOR) is a condition of utmost clinical and scientific relevance because of its negative influence on patient outcomes. The current methods of infertility treatment may be unsuitable for many women with DOR, which support the need for development of additional approaches to achieve fertility restoration. Various techniques have been tried to improve the quality and increase the quantity of oocytes in DOR patients, including mitochondrial transfer, activation of primordial follicles, in vitro culture of follicles, and regeneration of oocytes from various stem cells. Herein, we review the science behind these experimental reproductive technologies and their potential use to date in clinical studies for infertility treatment in women with DOR.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Fertility and Advanced Reproductive Medicine Assisted Reproductive Technologies Program, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Zexu Jiao & Orhan Bukulmez

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  1. Zexu Jiao
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  2. Orhan Bukulmez
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Correspondence to Zexu Jiao.

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Jiao, Z., Bukulmez, O. Potential roles of experimental reproductive technologies in infertile women with diminished ovarian reserve. J Assist Reprod Genet 38, 2507–2517 (2021). https://doi.org/10.1007/s10815-021-02246-6

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  • DOI: https://doi.org/10.1007/s10815-021-02246-6

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