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Cumulative probabilities of live birth across multiple complete IVF/ICSI cycles: a call for attention

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

To call attention to the fact that cumulative live birth (LB) proportions exhibit an inverted pattern to that displayed by each individual oocyte retrieval cycle (ORC-specific LB proportions) as well as when grouping together all the ORCs undergone by a woman (TNORC-specific LB proportions).

Methods

A retrospective study of 1433 infertile women that had a LB using autologous fresh or frozen embryos and/or dropped out of IVF/ICSI treatment after completing a maximum number of three treatment cycles. Generalized Estimating Equations (GEE) and standard and landmark Kaplan-Meier survival analyses were applied.

Results

A standard Kaplan-Meier analysis indicated that cumulative LB proportions rose as number of ORCs increased (0.320, 0.484, and 0.550 at ORC 1, 2, and 3, respectively). In contrast, landmark ORC-specific LB proportions showed an inverted pattern (0.320, 0.242, and 0.127 at ORC 1, 2, and 3, respectively). GEE models revealed that women’s clinical outcomes decreased as TNORCs increased. In particular, compared to women that experienced just one ORC, women that underwent two and three ORCs displayed higher incidences of cycle cancellations before either oocyte retrieval or embryo transfer, and clinical pregnancy losses, and lower odds of LB.

Conclusion

Infertile women should be informed that cumulative LB probabilities exhibit an inverted pattern to that displayed by each individual ORC as well as when grouping together all the ORCs undergone by a woman.

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Authors and Affiliations

  1. Department of Cellular Biology, Functional Biology and Physical Anthropology, Faculty of Biological Sciences, University of Valencia, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain

    Juan J. Tarín & Eva Pascual

  2. Institute of Health Research INCLIVA, Valencia, Spain

    Juan J. Tarín, Raúl Gómez, Miguel A. García-Pérez & Antonio Cano

  3. Unitat d’Estadística i Bioinformàtica (UEB), Vall d’Hebron Research Institute (VHIR), Barcelona, Spain

    Santiago Pérez-Hoyos

  4. Department of Genetics, Faculty of Biological Sciences, University of Valencia, Burjassot, Valencia, Spain

    Miguel A. García-Pérez

  5. Service of Obstetrics and Gynecology, University Clinic Hospital, Valencia, Spain

    Antonio Cano

  6. Department of Pediatrics, Obstetrics and Gynecology, Faculty of Medicine, University of Valencia, Valencia, Spain

    Antonio Cano

Authors
  1. Juan J. Tarín
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  2. Eva Pascual
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  3. Santiago Pérez-Hoyos
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  4. Raúl Gómez
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  5. Miguel A. García-Pérez
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  6. Antonio Cano
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Corresponding author

Correspondence to Juan J. Tarín.

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This study was approved by the Ethical Committee of Clinical Investigation, Valencia University Clinical Hospital on November 30th 2017 (2017/316). Written informed consent was not required from the participants because the retrospective nature of the study.

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Tarín, J.J., Pascual, E., Pérez-Hoyos, S. et al. Cumulative probabilities of live birth across multiple complete IVF/ICSI cycles: a call for attention. J Assist Reprod Genet 37, 141–148 (2020). https://doi.org/10.1007/s10815-019-01608-5

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  • DOI: https://doi.org/10.1007/s10815-019-01608-5

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