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Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

  • Assisted Reproduction Technologies
  • Published:
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Abstract

Purpose

To establish a ratio of the P level to the number of follicles (P/F ratio) on the day of human chorionic gonadotropin (hCG) administration and to evaluate whether this ratio is associated with in vitro fertilization (IVF) outcome.

Methods

This study was conducted between January 2012 and June 2013. A total of 337 patients with cleavage-stage day-3 fresh embryo transfer with P levels ≤1.5 ng/mL on the day of hCG administration were included in the study. The main outcome was ongoing pregnancy rate.

Result(s)

The P/F ratio was calculated according to the equation (P[ng/mL]/number of follicles) on the day of final oocyte maturation. Using ROC, we established a cut-off level of 0.075 for the P/F ratio. The area under the curve (AUC) (0.756; 95 % confidence interval [CI]: 0.704–0.807) indicated that it was a good prognostic test. In group 1 (patients under 36 years old), the ongoing pregnancy rates were 57 and 30 % for patients with P/F ratios ≤ .075 and > .075, respectively, (p = 0.003). In group 2 (patients between 36 and 39 years old), the ongoing pregnancy rates were 58 % and 17 % (p = 0.001) for patients with P/F ratios ≤ .075 and > .075, respectively. In group 3 (patients ≥ 40 years old), the ongoing pregnancy rates were 41.7 and 10.9 % (p = 0.001) for patients with P/F ratios ≤ .075 and > .075, respectively.

Conclusions

The P/F ratio is a good prognostic test for predicting IVF outcome that can correlate the P level with ovarian response.

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Acknowledgments

Conflict of interest

The authors declare that they have no conflict of interest

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Authors and Affiliations

  1. ORIGEN—Center for Reproductive Medicine, Avenida Rodolfo de Amoedo, 140, Barra da Tijuca, Rio de Janeiro, Brazil

    Matheus Roque, Marcello Valle & Marcos Sampaio

  2. ORIGEN—Center for Reproductive Medicine, Avenida do Contorno, 7747 Lourdes, Belo Horizonte, Brazil

    Selmo Geber

  3. Universidade Federal de Minas Gerais, Avenida Alfredo Balena, 190, Belo Horizonte, Brazil

    Selmo Geber

  4. Department of Obstetrics and Gynecology, Parc de Salut Mar, Universitat Autonoma de Barcelona, PasseigMarítim 25-29, 08003, Barcelona, Spain

    Miguel Angel Checa

Authors
  1. Matheus Roque
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  2. Marcello Valle
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  3. Marcos Sampaio
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  4. Selmo Geber
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  5. Miguel Angel Checa
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Correspondence to Matheus Roque.

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Capsule The ratio of progesterone-to-number of follicles is a good prognostic test for predicting IVF outcome that can correlate the P level with ovarian response.

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Roque, M., Valle, M., Sampaio, M. et al. Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles. J Assist Reprod Genet 32, 951–957 (2015). https://doi.org/10.1007/s10815-015-0487-1

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  • DOI: https://doi.org/10.1007/s10815-015-0487-1

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