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Low level of red seaweed Pyropia columbina added to extruded maize products promotes colonic and systemic antioxidant environment in growing Wistar rats

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Abstract

The aim of this work was to evaluate the effect of consumption of extruded maize product added with a low level of the red seaweed Pyropia columbina on colonic and systemic oxidative status using a growing Wistar rat model. Twenty-four (n = 24) male Wistar rats were fed for 60 days with control (C), extruded maize product group (M), or extruded maize product added with red seaweed P. columbina (MP) diets. Rats fed whit MP showed higher catalase (CAT) and glutathione reductase (GR) colon expression than those fed with M or C. Beneficial effects on intestinal mucosal barrier function were observed, which was manifested in decrease of cecal pH (10%) and mucinase activity (67%) and increase of sIgA content (53%). Rats fed with MP diet showed lower cyclooxygenase-2 (COX-2; 43%), inducible nitric oxide synthase (iNOS; 49%), and NF-κβ transcription factor (27%) expression in distal colon than those fed with M or C diets. Also, MP diet exerted a significant antioxidant effect on the serum and liver, increasing hepatic redox index, CAT, and GR activity. Apparent calcium absorption, total skeleton bone mineral content, and bone mineral density of total body were the same among groups. The type of dietary fiber and phenolic compounds from P. columbina could promote antioxidant environment in growing Wistar rats.

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Acknowledgements

All authors read and approved the final manuscript. The authors are thankful to CAI + D 2011 PI 0292 LI of the Universidad Nacional del Litoral for the financial support.

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Authors and Affiliations

  1. Instituto de Tecnología de Alimentos, CONICET, FIQ – UNL, 1° de Mayo 3250, (3000), Santa Fe, Argentina

    Raúl E. Cian, Emilce Llopart & Silvina R. Drago

  2. Sección Departamental de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain

    María E. López-Oliva Muñoz

  3. Departamento de Bromatología y Nutrición, Facultad de Farmacia y Bioquímica, (UBA), Buenos Aires, Argentina

    Adriana R. Weisstaub & Ángela Zuleta

Authors
  1. Raúl E. Cian
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  2. Emilce Llopart
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  3. María E. López-Oliva Muñoz
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  4. Adriana R. Weisstaub
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  5. Ángela Zuleta
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  6. Silvina R. Drago
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Correspondence to Raúl E. Cian.

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Cian, R.E., Llopart, E., López-Oliva Muñoz, M.E. et al. Low level of red seaweed Pyropia columbina added to extruded maize products promotes colonic and systemic antioxidant environment in growing Wistar rats. J Appl Phycol 30, 637–648 (2018). https://doi.org/10.1007/s10811-017-1259-3

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  • DOI: https://doi.org/10.1007/s10811-017-1259-3

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