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Looking Back at the Next 40 Years of ASD Neuroscience Research

  • S.I. :Autism in Review: 1980-2020: 40 years after DSM-III
  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

During the last 40 years, neuroscience has become one of the most central and most productive approaches to investigating autism. In this commentary, we assemble a group of established investigators and trainees to review key advances and anticipated developments in neuroscience research across five modalities most commonly employed in autism research: magnetic resonance imaging, functional near infrared spectroscopy, positron emission tomography, electroencephalography, and transcranial magnetic stimulation. Broadly, neuroscience research has provided important insights into brain systems involved in autism but not yet mechanistic understanding. Methodological advancements are expected to proffer deeper understanding of neural circuitry associated with function and dysfunction during the next 40 years.

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Acknowledgments

Support was provided by the Hilibrand Foundation (JM, DT), Alan B. Slifka Foundation (JM), NIMH U19 MH108206 (JM), NIMH R01 MH100173 (JM), NIMH R01 MH107426 (JM), NIMH R01 MH111629 (JM), NIMH R21 MH122202 (JM), NIMH R21 MH113955 (DM, JM), NARSAD Young Investigator Award Grant from the Brain & Behavior Foundation ID 27542 (DM), NICHD R03 HD100771 (AJ), NIMH R01 MH100028 (AJ), George Mason Department of Psychology (AJ, GAM), Stony Brook Renaissance School of Medicine (MDL), Autism Research Institute (MDL), Society of Clinical Child and Adolescent Psychology (MDL), NIMH R01 MH114906 (MDL), NIMH R01 MH110585 (MDL), Autism Speaks Postdoctoral Fellowship POID 11808 (GAM), Dana Foundation (AB), NIH NIGMS IDEA P20 GM103446 (AB), F31MH122091 (TC), the Temple University Public Policy Lab Graduate Fellowship (TC), the American Psychological Association (APA) Dissertation Research Award (TC), and the Dr. Phillip J Bersh Memorial Student Award (TC).

Author information

Authors and Affiliations

  1. Child Study Center, Yale School of Medicine, New Haven, CT, 06520, USA

    James C. McPartland & Dominic A. Trevisan

  2. Department of Psychology, Stony Brook University, Stony Brook, NY, USA

    Matthew D. Lerner

  3. Department of Physical Therapy, University of Delaware, Newark, DE, USA

    Anjana Bhat & Wan-Chun Su

  4. Department of Psychology, Temple University, Philadelphia, PA, USA

    Tessa Clarkson

  5. Department of Psychology, George Mason University, Fairfax, VA, USA

    Allison Jack & Goldie A. McQuaid

  6. Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA

    Sheida Koohsari & David Matuskey

  7. Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA

    David Matuskey

  8. Department of Neurology, Yale School of Medicine, New Haven, CT, USA

    David Matuskey

Authors
  1. James C. McPartland
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  2. Matthew D. Lerner
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  3. Anjana Bhat
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  4. Tessa Clarkson
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  5. Allison Jack
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  6. Sheida Koohsari
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  7. David Matuskey
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  8. Goldie A. McQuaid
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  9. Wan-Chun Su
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  10. Dominic A. Trevisan
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Contributions

JM and ML contributed to manuscript design. All authors contributed to writing and editing the manuscript, and all authors approved the final manuscript.

Corresponding author

Correspondence to James C. McPartland.

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Conflict of Interest

JM consults with Customer Value Partners, Bridgebio, Determined Health, and BlackThorn Therapeutics, has received research funding from Janssen Research and Development, serves on the Scientific Advisory Boards of Pastorus and Modern Clinics, and receives royalties from Guilford Press, Lambert, and Springer.

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McPartland, J.C., Lerner, M.D., Bhat, A. et al. Looking Back at the Next 40 Years of ASD Neuroscience Research. J Autism Dev Disord 51, 4333–4353 (2021). https://doi.org/10.1007/s10803-021-05095-5

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  • DOI: https://doi.org/10.1007/s10803-021-05095-5

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