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Electrochemical sensing of rifampicin in pharmaceutical samples using meso-tetrakis(4-hydroxyphenyl)porphyrinato cobalt(II) anchored carbon nanotubes

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Abstract

In this work, an electrochemical sensing platform is prepared for rifampicin determination based on multiwalled carbon nanotubes (MWCNTs) modified with meso-tetrakis(4-hydroxyphenyl)porphyrinato cobalt(II) (CoTHPP) nanocomposite (abbreviated as MWCNTs-CoTHPP). The material is characterized by different techniques such as UV–Vis, Fourier transform-infrared, Raman, transmission electron microscopy, scanning electron microscopy, and energy dispersive X-ray analysis. For the electrochemical sensing platform, the nanocomposite, MWCNTs-CoTHPP is immobilized on glassy carbon (GC) electrode (represented as GC/MWCNTs-CoTHPP) and applied for electrochemical recognition of rifampicin. It is found that the GC/MWCNTs-CoTHPP electrode facilitates the electrochemical oxidation of rifampicin with decreased overpotential in 0.1 M acetate buffer (pH 4.7). Further, GC/MWCNTs-CoTHPP exhibits broad calibration range (0.01 µM–5.0 mM), high sensitivity (217 µA mM−1 cm−2), high reproducibility (relative standard deviation = 4.83%, n = 6), and low detection limit (0.008 µM) for rifampicin determination. In addition, this method is successfully applied for real sample (rifampicin capsule) analysis with consistent results. The results suggest that MWCNTs-CoTHPP is a potential candidate for an effective, rapid, and simple electrochemical sensor to detect rifampicin in pharmaceutical formulations.

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Acknowledgements

The authors gratefully acknowledge the financial support by DST (SR/NM/NS-2012/2013(G)), New Delhi, India. We are pleased to thank Prof. R.K. Singh, Banaras Hindu University for Raman characterization and Dr. S.A. John, Gandhigram Rural University for SEM and useful suggestions. MS sincerely thanks Science and Engineering Research Board (EMR/2016/004016) for the financial support. KP thanks Ministry of Human Resource Development, India for Senior Research Fellowship.

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Authors and Affiliations

  1. Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, UP, 221 005, India

    Piyush Kumar Sonkar, Mamta Yadav, Vellaichamy Ganesan, Dharmendra Kumar Yadav & Rupali Gupta

  2. Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India

    Kamal Prakash & Muniappan Sankar

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  1. Piyush Kumar Sonkar
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Correspondence to Vellaichamy Ganesan.

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Sonkar, P.K., Yadav, M., Prakash, K. et al. Electrochemical sensing of rifampicin in pharmaceutical samples using meso-tetrakis(4-hydroxyphenyl)porphyrinato cobalt(II) anchored carbon nanotubes. J Appl Electrochem 48, 937–946 (2018). https://doi.org/10.1007/s10800-018-1221-3

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