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Herpes simplex virus keratitis: electronic medical records driven big data analytics report from a tertiary eye institute of South India

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Abstract

Objective

To describe the demographics and clinical profile of Herpes Simplex Virus (HSV) Keratitis in patients presenting to a multi-tier ophthalmology hospital network in South India.

Methods

We have reviewed the medical records of all patients having a clinical diagnosis of any form of HSV keratitis, seen between May 2012 and August 2020 across the L V Prasad Eye Institute network. All the further analyses of the groups were performed using the keywords used for making the diagnosis of HSV keratitis and the data were collected from the electronic medical record system.

Results

There were a total of 8308 (N = 8897 eyes) patients. Male: female ratio was 5368 (64.61%):2940 (35.39%). Unilateral involvement was in 7719 (92.91%) patients. The most common age group affected was between the third to fifth decades of life with 1544 (18.58%). 3708 (1.68%) eyes had mild visual impairment (< 20/70) while the rest of them had moderate to severe visual impairment as observed mainly (p ≤ 0.01) in Necrotizing stromal keratitis. 7314 (82.21%) eyes had normal intraocular pressure (10–21 mm Hg) while raised most commonly in keratouveitis (P ≤ 0.01). Epithelial Keratitis, Immune Stromal Keratitis, Endotheliitis, Neurotrophic keratopathy and Keratouveitis were observed in 1875 (17.22%) eyes, 5430 (61.03%) eyes, in 129(1.45%) eyes, 1188 (13.35%) eyes, 148 (1.66%) eyes and 256 (2.88%) eyes respectively.

Conclusion

Based on our institute-based data, the most common type of HSV keratitis is Immune stromal keratitis followed by epithelial keratitis. Although not representative of the general population, this data provide useful insights related to HSV keratitis from India.

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References

  1. Liesegang TJ, Melton LJ 3rd, Daly PJ, Ilstrup DM (1989) Epidemiology of ocular herpes simplex. Incidence in Rochester, Minn, 1950 through 1982. Arch Ophthalmol 107(8):1155–1159

    Article  CAS  PubMed  Google Scholar 

  2. Farooq AV, Shukla D (2012) Herpes simplex epithelial and stromal keratitis: an epidemiologic update. Surv Ophthalmol 57(5):448–462

    Article  PubMed  PubMed Central  Google Scholar 

  3. McCormick I, James C, Welton NJ, Mayaud P, Turner KME, Gottlieb SL et al (2022) Incidence of herpes simplex virus keratitis and other ocular disease: global review and estimates. Ophthalmic Epidemiol 29(4):353–362

    Article  PubMed  Google Scholar 

  4. Darougar S, Wishart MS, Viswalingam ND (1985) Epidemiological and clinical features of primary herpes simplex virus ocular infection. Br J Ophthalmol 69(1):2–6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Labetoulle M, Auquier P, Conrad H, Crochard A, Daniloski M, Bouee S et al (2005) Incidence of herpes simplex virus keratitis in France. Ophthalmology 112(5):888–895

    Article  CAS  PubMed  Google Scholar 

  6. Miserocchi E, Fogliato G, Bianchi I, Bandello F, Modorati G (2014) Clinical features of ocular herpetic infection in an Italian referral center. Cornea 33(6):565–570

    Article  PubMed  Google Scholar 

  7. Smith JS, Robinson NJ (2002) Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review. J Infect Dis 186(Suppl 1):S3-28

    Article  PubMed  Google Scholar 

  8. Stanzel TP, Diaz JD, Mather R, Wong IG, Margolis TP, Gritz DC (2014) The epidemiology of herpes simplex virus eye disease in Northern California. Ophthalmic Epidemiol 21(6):370–377

    Article  PubMed  Google Scholar 

  9. Young RC, Hodge DO, Liesegang TJ, Baratz KH (2010) Incidence, recurrence, and outcomes of herpes simplex virus eye disease in Olmsted County, Minnesota, 1976–2007: the effect of oral antiviral prophylaxis. Arch Ophthalmol 128(9):1178–1183

    Article  PubMed  PubMed Central  Google Scholar 

  10. Whitcher JP, Dawson CR, Hoshiwara I, Daghfous T, Messadi M, Triki F et al (1976) Herpes simplex keratitis in a developing country. Natural history and treatment of epithelial ulcers in Tunisia. Arch Ophthalmol 94(4):587–592

    Article  CAS  PubMed  Google Scholar 

  11. Bajracharya L, Bade AR, Gurung R, Dhakhwa K (2020) Demography, risk factors, and clinical and microbiological features of microbial keratitis at a tertiary eye hospital in Nepal. Clin Ophthalmol 14:3219–3226

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ashaye A, Aimola A (2008) Keratitis in children as seen in a tertiary hospital in Africa. J Natl Med Assoc 100(4):386–390

    PubMed  Google Scholar 

  13. Pepose JS, Keadle TL, Morrison LA (2006) Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy. Am J Ophthalmol 141(3):547–557

    Article  PubMed  Google Scholar 

  14. Pramod NP, Gopalakrishnan V, Mohan R, Chandriga S, Anandakannan K, Menon T et al (1998) Enhanced detection of herpes simplex virus from ocular specimens of herpetic keratitis patients. Indian J Pathol Microbiol 41(1):49–53

    CAS  PubMed  Google Scholar 

  15. Roy A, Fernandes M, Das S (2021) How much clinical practice is aligned with the Herpetic Eye Disease Study! Indian J Ophthalmol 69(5):1339–1340

    Article  PubMed  PubMed Central  Google Scholar 

  16. Satpathy G, Mishra AK, Tandon R, Sharma MK, Sharma A, Nayak N et al (2011) Evaluation of tear samples for Herpes Simplex Virus 1 (HSV) detection in suspected cases of viral keratitis using PCR assay and conventional laboratory diagnostic tools. Br J Ophthalmol 95(3):415–418

    Article  PubMed  Google Scholar 

  17. Pramod NP, Rajendran P, Kannan KA, Thyagarajan SP (1999) Herpes simplex keratitis in South India: clinico-virological correlation. Jpn J Ophthalmol 43(4):303–307

    Article  CAS  PubMed  Google Scholar 

  18. Das AV, Kammari P, Vadapalli R, Basu S (2020) Big data and the eyeSmart electronic medical record system - an 8-year experience from a three-tier eye care network in India. Indian J Ophthalmol 68(3):427–432

    Article  PubMed  PubMed Central  Google Scholar 

  19. Holland EJ, Schwartz GS (1999) Classification of herpes simplex virus keratitis. Cornea 18(2):144–154

    Article  CAS  PubMed  Google Scholar 

  20. Chodosh J, Ung L (2020) Adoption of innovation in herpes simplex virus keratitis. Cornea 39(Suppl 1):S7–S18

    Article  PubMed  PubMed Central  Google Scholar 

  21. Bagga B, Kate A, Joseph J, Dave VP (2020) Herpes simplex infection of the eye: an introduction. Commun Eye Health 33(108):68–70

    Google Scholar 

  22. Donthineni PR, Kammari P, Shanbhag SS, Singh V, Das AV, Basu S (2019) Incidence, demographics, types and risk factors of dry eye disease in India: electronic medical records driven big data analytics report I. Ocul Surf 17(2):250–256

    Article  PubMed  Google Scholar 

  23. The prevention of blindness. Report of a WHO Study Group (1973) World Health Organ Tech Rep Ser. 518:1–18

  24. Hochberg CH, Schneider JA, Dandona R, Lakshmi V, Kumar GA, Sudha T et al (2015) Population and dyadic-based seroincidence of herpes simplex virus-2 and syphilis in southern India. Sex Transm Infect 91(5):375–382

    Article  PubMed  Google Scholar 

  25. Das AV, Chaurasia S, Joseph J, Roy A, Das S, Fernandes M (2022) Clinical profile and microbiological trends of therapeutic keratoplasty at a network of tertiary care ophthalmology centers in India. Int Ophthalmol 42(5):1391–1399

    Article  PubMed  Google Scholar 

  26. Novak N, Peng WM (2005) Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells. Clin Exp Immunol 142(3):405–410

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Lairson DR, Begley CE, Reynolds TF, Wilhelmus KR (2003) Prevention of herpes simplex virus eye disease: a cost-effectiveness analysis. Arch Ophthalmol 121(1):108–112

    Article  PubMed  Google Scholar 

  28. Erdem E, Harbiyeli II, Ozturk G, Oruz O, Acikalin A, Yagmur M et al (2020) Atypical herpes simplex keratitis: frequency, clinical presentations and treatment results. Int Ophthalmol 40(3):659–665

    Article  PubMed  Google Scholar 

  29. Shimomura Y, Higaki S (2011) The kinetics of herpes virus on the ocular surface and suppression of its reactivation. Cornea 30(Suppl 1):S3-7

    Article  PubMed  Google Scholar 

  30. Wilhelmus KR, Falcon MG, Jones BR (1981) Bilateral herpetic keratitis. Br J Ophthalmol 65(6):385–387

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Ma JX, Wang LN, Zhou RX, Yu Y, Du TX (2016) Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis. Int J Ophthalmol 9(5):682–686

    PubMed  PubMed Central  Google Scholar 

  32. Alfaro Rangel R, Lepper S, Szentmary N, Langenbucher A, Seitz B (2021) Herpes simplex virus keratitis in a university tertiary referral centre - clinical features and surgical approaches. Klin Monbl Augenheilkd 238(9):989–995

    Article  PubMed  Google Scholar 

  33. Pramod NP, Thyagarajan SP, Mohan KV, Anandakannan K (2000) Polymerase chain reaction in the diagnosis of herpetic keratitis: experience in a developing country. Can J Ophthalmol 35(3):134–140

    Article  CAS  PubMed  Google Scholar 

  34. Guess S, Stone DU, Chodosh J (2007) Evidence-based treatment of herpes simplex virus keratitis: a systematic review. Ocul Surf 5(3):240–250

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors wish to acknowledge the support of our Department of eyeSmart EMR & AEye team specially Mr. Ranganath Vadapalli and Mr. Mohammad Pasha.

Funding

By-Hyderabad Eye Research Foundation, India.

Author information

Authors and Affiliations

  1. Department of eyeSmart EMR & AEye, L V Prasad Eye Institute, Hyderabad, Telangana, India

    Anthony Vipin Das

  2. Indian Health Outcomes, Public Health and Economics Research Center, L V Prasad Eye Institute, Hyderabad, Telangana, India

    Anthony Vipin Das

  3. Manipal Academy of Higher Education, Manipal, Karnataka, India

    Gagan Satyashree

  4. Jhaveri Microbiology Centre, L V Prasad Eye Institute, Hyderabad, Telangana, India

    Joveeta Joseph

  5. Ramoji foundation Centre of Ocular Infections, Hyderabad, India

    Gagan Satyashree, Joveeta Joseph & Bhupesh Bagga

  6. The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, 500034, India

    Bhupesh Bagga

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The corresponding author states that authorship credit of this manuscript was based on (1) substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; (2) drafting the article or revising it critically for important intellectual content; and (3) final approval of the version to be published. All listed authors met conditions 1, 2, and 3. All persons designated as authors qualify for authorship, and all those who qualify are listed. Each author has participated sufficiently in the work to take public responsibility for appropriate portions of the content.

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Correspondence to Bhupesh Bagga.

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Das, A.V., Satyashree, G., Joseph, J. et al. Herpes simplex virus keratitis: electronic medical records driven big data analytics report from a tertiary eye institute of South India. Int Ophthalmol 43, 4669–4676 (2023). https://doi.org/10.1007/s10792-023-02866-0

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