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Diagnostic efficacy of elevated serum angiotensin-converting enzyme and lymphopenia between presumed sarcoid uveitis and presumed tubercular uveitis

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Abstract

Purpose

To evaluate the diagnostic efficacy of elevated serum angiotensin-converting enzyme (sACE) and lymphopenia in presumed sarcoid and tubercular uveitis.

Methods

A single-centre retrospective study was conducted on a cohort of 755 adult patients with uveitis between January 2019 and June 2020. Demographic, clinical and laboratory data were retrieved from our hospital database. Measurements of serum angiotensin-converting enzyme (sACE) and lymphocyte counts were analysed.

Results

The mean age of the patients was 41 ± 13 years. Presumed sarcoid uveitis was diagnosed in 50 (7%) patients, presumed tubercular uveitis in 222 (29.4%) and other uveitic entities noted in 483 (64%). Intermediate and posterior uveitis were the most common anatomical diagnosis in presumed sarcoid uveitis (59% and 20%, respectively) and in presumed tubercular uveitis (46% and 38%, respectively). Elevated sACE was noted in 76% of presumed sarcoid uveitis and 46% in presumed tubercular uveitis. The combination of high serum angiotensin-converting enzyme along with lymphopenia was only in 17% in presumed sarcoid uveitis and 9.7% in presumed tubercular uveitis. sACE was found to be a significant risk factor for presumed sarcoid uveitis with an odds ratio of 3.603 (p < 0.002), and in presumed tubercular uveitis odds ratio was not significant with odds ratio of 1.19. Lymphopenia was not found to be a significant factor in both groups.

Conclusion

Elevated sACE activity was an independent risk factor for presumed sarcoid uveitis over lymphopenia alone or in combination with lymphopenia.

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Funding

This research project has nil funding.

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Authors and Affiliations

  1. Department of Uvea, Medical Research Foundation, Sankara Nethralaya, Chennai, India

    Nandhini Elango & Jeyasooriya Ramdoss

  2. Medical Research Foundation, Sankara Nethralaya, Chennai, India

    Jayanthi Udayakumar, Snehal H. Bavaskar, Punitham Ranganathan & Angayarkanni Narayanasamy

  3. RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Chennai, India

    Bharathidevi Subramaniam Rajesh

  4. Director of Uveitis and Ocular Pathology Department, Medical Research Foundation, Sankara Nethralaya, Chennai, India

    Jyotirmay Biswas

Authors
  1. Nandhini Elango
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  2. Jeyasooriya Ramdoss
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  3. Jayanthi Udayakumar
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  4. Snehal H. Bavaskar
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  5. Punitham Ranganathan
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  6. Bharathidevi Subramaniam Rajesh
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  7. Angayarkanni Narayanasamy
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  8. Jyotirmay Biswas
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by NE, JR, JU, Dr. SHB, PR, Dr. BSR, Dr. AN, Dr. JB. The first draft of the manuscript was written by NE, JR, Dr. AN, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jyotirmay Biswas.

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Elango, N., Ramdoss, J., Udayakumar, J. et al. Diagnostic efficacy of elevated serum angiotensin-converting enzyme and lymphopenia between presumed sarcoid uveitis and presumed tubercular uveitis. Int Ophthalmol 43, 3651–3657 (2023). https://doi.org/10.1007/s10792-023-02773-4

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  • DOI: https://doi.org/10.1007/s10792-023-02773-4

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