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Angiolymphoid hyperplasia with eosinophilia: a case series and literature review

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Abstract

Purpose

Angiolymphoid hyperplasia with eosinophilia is an uncommon chronic inflammatory condition of unknown etiology. Orbital and adnexal involvement findings are variable and often nonspecific.

Methods and Result

We report six patients with angiolymphoid hyperplasia of the orbit, their clinical and histopathological characteristics, and a review of previously published literature with this diagnosis between 1980 and 2021.

Conclusion

ALHE has definite histopathologic features but inconclusive radiological studies. The ophthalmologic findings of this entity overlap significantly with other similar variants and may be thought as equivalent lesions.

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Data availability

Data are available upon a reasonable request from the authors.

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Acknowledgements

NA.

Funding

The study was not funded by any agency.

Author information

Authors and Affiliations

  1. Oculoplastic and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

    Abdulrahman Alfarhan & Humoud M. Alotaibi

  2. Pathology and Laboratory Medicine, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

    Azza Maktabi

  3. Oculoplastic Department, Ophthalmology Center, Ohud Hospital, Medina, Saudi Arabia

    Mohammed M. Alofi

  4. Adjunct Lecturer at College of Medicine, Alfaisal University, Riyadh, Saudi Arabia

    Humoud M. Alotaibi

Authors
  1. Abdulrahman Alfarhan
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  2. Azza Maktabi
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  3. Mohammed M. Alofi
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  4. Humoud M. Alotaibi
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Contributions

All authors participated in the study design. AA and AM participated in the data management and analysis. AA wrote the introduction section, MA wrote the methods and results sections, and AA wrote the discussion section. MA and HM interpreted the results and edited all of the sections. AM critically reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Abdulrahman Alfarhan.

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Authors declare no conflict or competing interests.

Ethics approval

The study was approved by the ethic’s board of King Khaled Eye Specialist Hospital.

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Alfarhan, A., Maktabi, A., Alofi, M.M. et al. Angiolymphoid hyperplasia with eosinophilia: a case series and literature review. Int Ophthalmol 43, 2457–2467 (2023). https://doi.org/10.1007/s10792-023-02644-y

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  • DOI: https://doi.org/10.1007/s10792-023-02644-y

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